Your Microbiome Holds The Key To Curing Parkinson’s | Sarkis Mazmanian, PhD x Rich Roll

Rich Roll

May 9, 2024

Episode description

Rich sits down with Caltech microbiome research scientist & microbiology professor Dr. Sarkis Mazmanian to talk about how gut microbes influence neurological health, behavior, and conditions like Parkinson’s, autism, and depression. To read more about Dr. Mazmanian and peruse the full show notes, go here👉🏾https://bit.ly/richroll831

​​This Episode Brought To You By...

SQUARESPACE
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ON
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Check out all of the amazing discounts from our Sponsors 👉 https://bit.ly/rrpsponsors

✌🏼🌱 - Rich

LISTEN / SUBSCRIBE TO THE PODCAST
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Meal Planner: http://meals.richroll.com
Voicing Change Book: http://richroll.com/vc
Clips Channel: https://www.youtube.com/c/RichRollPodcastClips
Newsletter: http://bit.ly/rollcallemail

CONNECT WITH RICH
✩ Website - http://richroll.com​
✩ Rich Roll Podcast - https://richroll.com/all-episodes/
✩ Instagram - https://www.instagram.com/richroll/
✩ Twitter - https://twitter.com/richroll
✩ Facebook - https://www.facebook.com/richrollfans
✩ Strava - https://www.strava.com/athletes/14443?oq=rich
✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/
✩ Meals - http://meals.richroll.com​
✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/
✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/
✩ Support - https://www.patreon.com/richroll

FILMED AND EDITED BY BLAKE CURTIS & DAN DRAKE
https://www.blakecurtis.net/
https://www.dandrake333.com/

TIMESTAMPS
00:00:00 Intro
00:01:29 Introduction To Microbiome Research
00:04:23 Defining The Microbiome
00:06:11 Acceptance Of The Microbiome
00:07:53 Caltech As A Research Environment
00:09:04 The Gut-Brain Axis
00:13:52 Co-Evolution Of Microbiota And Humans
00:18:25 The Hygiene Hypothesis
00:20:45 Factors Affecting Microbiome Health
00:21:35 Building The Microbiome
00:22:26 Prenatal And Early Life Microbiome
00:24:39 Flexibility Of Adult Microbiome
00:26:27 Microbiome And Potential For Disease Transmission
00:29:49 Sponsor Break
00:30:55 Genetics And Microbiome Interaction
00:32:42 Environmental Triggers And Microbiome
00:35:55 Parkinson's And Gut Microbiome
00:41:55 Autism And The Microbiome
00:45:42 The Gut-Brain Axis And 4EPS
00:47:58 Oligodendrocyte Biology And Myelination
00:49:42 Parkinson's And Alpha-Synuclein Aggregation
00:52:55 Inhibition Of Bacterial Protein As Therapy
00:54:09 The Vagus Nerve And Parkinson's
00:57:01 Challenges In Translating Findings From Rodents To Humans
01:01:31 Sponsor Break
01:02:37 FDA's Perspective On Microbiome-Based Therapeutics
01:05:14 Direct Testing In Humans
01:06:27 The Effect Size Of Drugs
01:07:35 Research Landscape Of Neurological Disorders
01:08:36 Microbiome And Depression
01:11:06 Bi-Directional Communication Between Gut And Brain
01:13:29 Future Interventions For Microbiome-Based Therapies
01:15:56 Challenges And Potential Of Fecal Transplants
01:19:05 Complexity Of Microbiome Data
01:21:35 Dream Experiment For Studying Microbiome Impact
01:26:29 Influence Of Gut Microbiome On Food Cravings
01:29:12 The Microbiome And Sugar Cravings
01:30:17 Microbiome's Potential Impact On Addiction
01:32:10 Impact Of Diet On Microbiome And Cravings
01:35:50 The Microbiome's Influence On Sentience
01:38:57 Lifestyle Factors And Microbiome Health
01:40:30 The Role Of Fiber And Plant-Based Diets
01:43:48 Challenges Of Microbiome Testing And Interpretation
01:46:27 Future Of Microbiome Research And Healthcare
01:48:16 Big Pharma's Stance On Microbiome Research
01:50:04 Big Pharma's Business Model
01:51:54 Intellectual Property And Genetic Modification
01:53:10 Challenges Of Genetically Modified Microbes
01:54:54 Axial's Clinical Approach
01:58:37 Parkinson's Intervention Development
02:01:34 Microbiology Renaissance
02:02:42 Educational Resources And Skepticism
02:04:12 Closing Remarks And Credits

* * * * *

NEW TO RICH?
Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
http://bit.ly/otillonyt
http://bit.ly/vegansglam

I LOVE MAIL! SEND IT HERE:
2630 Conejo Spectrum St.
Thousand Oaks, CA 91320

#richroll #richrollpodcast

Episode description

Rich sits down with Caltech microbiome research scientist & microbiology professor Dr. Sarkis Mazmanian to talk about how gut microbes influence neurological health, behavior, and conditions like Parkinson’s, autism, and depression. To read more about Dr. Mazmanian and peruse the full show notes, go here👉🏾https://bit.ly/richroll831

​​This Episode Brought To You By...

SQUARESPACE
Get 10% OFF with code RichRoll 👉 https://bit.ly/squarespace2024

ON
Use code RICHROLL10 at the checkout to get 10% OFF 👉 https://bit.ly/on2024

Check out all of the amazing discounts from our Sponsors 👉 https://bit.ly/rrpsponsors

✌🏼🌱 - Rich

LISTEN / SUBSCRIBE TO THE PODCAST
Apple Podcasts: http://bit.ly/rrpitunes
Spotify: http://bit.ly/rrpspotify
Google: http://bit.ly/rrpgooglepods

Meal Planner: http://meals.richroll.com
Voicing Change Book: http://richroll.com/vc
Clips Channel: https://www.youtube.com/c/RichRollPodcastClips
Newsletter: http://bit.ly/rollcallemail

CONNECT WITH RICH
✩ Website - http://richroll.com​
✩ Rich Roll Podcast - https://richroll.com/all-episodes/
✩ Instagram - https://www.instagram.com/richroll/
✩ Twitter - https://twitter.com/richroll
✩ Facebook - https://www.facebook.com/richrollfans
✩ Strava - https://www.strava.com/athletes/14443?oq=rich
✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/
✩ Meals - http://meals.richroll.com​
✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/
✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/
✩ Support - https://www.patreon.com/richroll

FILMED AND EDITED BY BLAKE CURTIS & DAN DRAKE
https://www.blakecurtis.net/
https://www.dandrake333.com/

TIMESTAMPS
00:00:00 Intro
00:01:29 Introduction To Microbiome Research
00:04:23 Defining The Microbiome
00:06:11 Acceptance Of The Microbiome
00:07:53 Caltech As A Research Environment
00:09:04 The Gut-Brain Axis
00:13:52 Co-Evolution Of Microbiota And Humans
00:18:25 The Hygiene Hypothesis
00:20:45 Factors Affecting Microbiome Health
00:21:35 Building The Microbiome
00:22:26 Prenatal And Early Life Microbiome
00:24:39 Flexibility Of Adult Microbiome
00:26:27 Microbiome And Potential For Disease Transmission
00:29:49 Sponsor Break
00:30:55 Genetics And Microbiome Interaction
00:32:42 Environmental Triggers And Microbiome
00:35:55 Parkinson's And Gut Microbiome
00:41:55 Autism And The Microbiome
00:45:42 The Gut-Brain Axis And 4EPS
00:47:58 Oligodendrocyte Biology And Myelination
00:49:42 Parkinson's And Alpha-Synuclein Aggregation
00:52:55 Inhibition Of Bacterial Protein As Therapy
00:54:09 The Vagus Nerve And Parkinson's
00:57:01 Challenges In Translating Findings From Rodents To Humans
01:01:31 Sponsor Break
01:02:37 FDA's Perspective On Microbiome-Based Therapeutics
01:05:14 Direct Testing In Humans
01:06:27 The Effect Size Of Drugs
01:07:35 Research Landscape Of Neurological Disorders
01:08:36 Microbiome And Depression
01:11:06 Bi-Directional Communication Between Gut And Brain
01:13:29 Future Interventions For Microbiome-Based Therapies
01:15:56 Challenges And Potential Of Fecal Transplants
01:19:05 Complexity Of Microbiome Data
01:21:35 Dream Experiment For Studying Microbiome Impact
01:26:29 Influence Of Gut Microbiome On Food Cravings
01:29:12 The Microbiome And Sugar Cravings
01:30:17 Microbiome's Potential Impact On Addiction
01:32:10 Impact Of Diet On Microbiome And Cravings
01:35:50 The Microbiome's Influence On Sentience
01:38:57 Lifestyle Factors And Microbiome Health
01:40:30 The Role Of Fiber And Plant-Based Diets
01:43:48 Challenges Of Microbiome Testing And Interpretation
01:46:27 Future Of Microbiome Research And Healthcare
01:48:16 Big Pharma's Stance On Microbiome Research
01:50:04 Big Pharma's Business Model
01:51:54 Intellectual Property And Genetic Modification
01:53:10 Challenges Of Genetically Modified Microbes
01:54:54 Axial's Clinical Approach
01:58:37 Parkinson's Intervention Development
02:01:34 Microbiology Renaissance
02:02:42 Educational Resources And Skepticism
02:04:12 Closing Remarks And Credits

* * * * *

NEW TO RICH?
Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
http://bit.ly/otillonyt
http://bit.ly/vegansglam

I LOVE MAIL! SEND IT HERE:
2630 Conejo Spectrum St.
Thousand Oaks, CA 91320

#richroll #richrollpodcast

Mindsip insights from this episode:

Question commercial microbiome tests for reliability

The speaker is skeptical of the 170+ companies offering microbiome analysis, as the field is not yet mature enough to provide reliable, actionable health advice from the data.

Maintain a healthy gut to suppress cravings for sugar

Research in mice reveals that a complex microbiome actively suppresses the desire for sugary and palatable foods, and its removal increases these cravings.

Rethink drug discovery: move beyond animal studies

Drug discovery often fails to translate to humans because research uses genetically identical mice in sterile environments, which doesn't model the complex gene-environment interactions of people.

Develop gut-retentive drug to halt Parkinson's progression

A therapeutic compound is being developed for Parkinson's that is gut-retentive, meaning it works entirely within the intestine to halt disease progression without entering circulation.

Investigate transmissibility of chronic diseases through microbiome sharing

A novel hypothesis suggests that diseases not normally considered communicable may be transmissible through the sharing of microbiomes between individuals who cohabitate.

Adapt adult microbiomes by changing environments

Contrary to older beliefs, recent research shows adult microbiomes are very flexible and can be significantly altered by changes in environment, such as moving in with a new person.

Utilize human microbes for superior health modulation

Microbes that have co-evolved with humans are likely more potent for modulating health than the vast majority of commercial probiotics, which typically come from dairy products.

Leverage gut bacteria to influence brain health

Dozens, and potentially hundreds, of molecules found in the human brain are produced exclusively by gut bacteria, which have evolved ways to cross the blood-brain barrier.

Clear microbiome to reverse Parkinson's symptoms in mice

In a key experiment, mice genetically predisposed to Parkinson's had all their motor and gut symptoms disappear after their microbiome was cleared out.

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