
Your Microbiome Holds The Key To Curing Parkinson’s | Sarkis Mazmanian, PhD x Rich Roll
Rich Roll
May 9, 2024
Mindsip insights from this episode:
Question commercial microbiome tests for reliability
The speaker is skeptical of the 170+ companies offering microbiome analysis, as the field is not yet mature enough to provide reliable, actionable health advice from the data.
Maintain a healthy gut to suppress cravings for sugar
Research in mice reveals that a complex microbiome actively suppresses the desire for sugary and palatable foods, and its removal increases these cravings.
Rethink drug discovery: move beyond animal studies
Drug discovery often fails to translate to humans because research uses genetically identical mice in sterile environments, which doesn't model the complex gene-environment interactions of people.
Develop gut-retentive drug to halt Parkinson's progression
A therapeutic compound is being developed for Parkinson's that is gut-retentive, meaning it works entirely within the intestine to halt disease progression without entering circulation.
Investigate transmissibility of chronic diseases through microbiome sharing
A novel hypothesis suggests that diseases not normally considered communicable may be transmissible through the sharing of microbiomes between individuals who cohabitate.
Adapt adult microbiomes by changing environments
Contrary to older beliefs, recent research shows adult microbiomes are very flexible and can be significantly altered by changes in environment, such as moving in with a new person.
Utilize human microbes for superior health modulation
Microbes that have co-evolved with humans are likely more potent for modulating health than the vast majority of commercial probiotics, which typically come from dairy products.
Leverage gut bacteria to influence brain health
Dozens, and potentially hundreds, of molecules found in the human brain are produced exclusively by gut bacteria, which have evolved ways to cross the blood-brain barrier.
Clear microbiome to reverse Parkinson's symptoms in mice
In a key experiment, mice genetically predisposed to Parkinson's had all their motor and gut symptoms disappear after their microbiome was cleared out.
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