Arterial Plaque Traps Inflammation - Fish Oil may Release it

Physionic

6 sept 2025

Episode description

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0:00 - Introduction
1:12 - Omega-3s and Plaque Stabilization
3:44 - Freeing Immune Cells
5:39 - Main Points

Reference
[A] Wang TM, Chen CJ, Lee TS, et al. Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells. J Nutr Biochem. 2011;22(2):187-194. doi:10.1016/j.jnutbio.2010.01.007

Clinical Data: https://youtu.be/jdYETp-JbXA?si=AZNmhxg657AEXRrw

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#fishoilbenefits #omega3 #heartdiseaseprevention

Episode description

Mindsip insights from this episode:

Guide immune cells from plaque using CCR7 protein

A protein called CCR7 can guide immune cells out of the plaque and into the lymphatic system, much like a plane being guided by runway lights.

#immune-system

#plaque

Utilize DHA to reduce immune cell adhesion in inflammation

In a pro-inflammatory environment, the omega-3 fat DHA shows a strong dose-response reduction in the adhesion proteins that allow immune cells to invade plaque.

#DHA

#inflammation

Reduce artery stickiness with omega-3 fats

Omega-3 fats reduce 'adhesion molecules' on artery walls, making it harder for immune cells to grab on and invade the plaque.

#artery

#omega-3

Address unstable arterial plaque to combat inflammation

Dangerous arterial plaque is often unstable because it's bloated with immune cells that have become pro-inflammatory in a failed attempt to clear out cholesterol.