Can Sunlight Protect Your Kidneys From Sugar Damage?

Episode description

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0:00 - Introduction
0:10 - Vitamin D and Kidney Health
4:21 - Evidence from UV, like from the Sun?
4:42 - Main Points

References
[Study 523] Zhang RM, Oh J, Wice BM, Dusso A, Bernal-Mizrachi C. Acute hyperglycemia induces podocyte apoptosis by monocyte TNF-α release, a process attenuated by vitamin D and GLP-1 receptor agonists. J Steroid Biochem Mol Biol. 2025;247:106676. doi:10.1016/j.jsbmb.2025.106676.

Funding/Conflicts: Mixed Funding [Public Funding: Supported by the National Institutes of Health/National Heart, Lung, and Blood Institute (R01HL09481806) and the U.S. Department of Veterans Affairs, VA Merit Award (I01BX003648). / Non-Profit Funding: American Heart Association Career Development Award (855967). // No direct Conflicts of Interest

[Study 524] Guo Y, Song Z, Zhou M, Yang Y, Zhao Y, Liu B, et al. Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF-α–ROS–p38 MAPK pathway. Oncotarget. 2017;8(32):53276-53287.

Funding/Conflicts: Public Funding [National Natural Science Foundation of China (No. 81370826; No. 81570612); Medical Key Talents Programs of Jiangsu Province (RC2011124); Clinical Medical Science Technology Special Project of Jiangsu Province (No. BL2014080); Fundamental Research Funds for the Central Universities of China; Jiangsu Province Ordinary University Graduate Research Innovation Project (KYLX15_0180).] // No direct Conflicts of Interest

[A] Kovesdy CP, Ahmadzadeh S, Anderson JE, Kalantar-Zadeh K. Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch Intern Med. 2008;168(4):397-403. doi:10.1001/archinternmed.2007.110

[B] Wang Y, Yang S, Zhou Q, Zhang H, Yi B. Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: a Systematic Review and Meta-Analysis. Kidney Blood Press Res. 2019;44(1):72-87. doi:10.1159/000498838

[C] Weller RB, Macintyre IM, Melville V, Farrugia M, Feelisch M, Webb DJ. The effect of daily UVA phototherapy for 2 weeks on clinic and 24-h blood pressure in individuals with mild hypertension. J Hum Hypertens. 2023;37(7):548-553. doi:10.1038/s41371-022-00729-2

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#vitamind #sunlightbenefits

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:10 - Vitamin D and Kidney Health
4:21 - Evidence from UV, like from the Sun?
4:42 - Main Points

References
[Study 523] Zhang RM, Oh J, Wice BM, Dusso A, Bernal-Mizrachi C. Acute hyperglycemia induces podocyte apoptosis by monocyte TNF-α release, a process attenuated by vitamin D and GLP-1 receptor agonists. J Steroid Biochem Mol Biol. 2025;247:106676. doi:10.1016/j.jsbmb.2025.106676.

Funding/Conflicts: Mixed Funding [Public Funding: Supported by the National Institutes of Health/National Heart, Lung, and Blood Institute (R01HL09481806) and the U.S. Department of Veterans Affairs, VA Merit Award (I01BX003648). / Non-Profit Funding: American Heart Association Career Development Award (855967). // No direct Conflicts of Interest

[Study 524] Guo Y, Song Z, Zhou M, Yang Y, Zhao Y, Liu B, et al. Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF-α–ROS–p38 MAPK pathway. Oncotarget. 2017;8(32):53276-53287.

Funding/Conflicts: Public Funding [National Natural Science Foundation of China (No. 81370826; No. 81570612); Medical Key Talents Programs of Jiangsu Province (RC2011124); Clinical Medical Science Technology Special Project of Jiangsu Province (No. BL2014080); Fundamental Research Funds for the Central Universities of China; Jiangsu Province Ordinary University Graduate Research Innovation Project (KYLX15_0180).] // No direct Conflicts of Interest

[A] Kovesdy CP, Ahmadzadeh S, Anderson JE, Kalantar-Zadeh K. Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch Intern Med. 2008;168(4):397-403. doi:10.1001/archinternmed.2007.110

[B] Wang Y, Yang S, Zhou Q, Zhang H, Yi B. Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: a Systematic Review and Meta-Analysis. Kidney Blood Press Res. 2019;44(1):72-87. doi:10.1159/000498838

[C] Weller RB, Macintyre IM, Melville V, Farrugia M, Feelisch M, Webb DJ. The effect of daily UVA phototherapy for 2 weeks on clinic and 24-h blood pressure in individuals with mild hypertension. J Hum Hypertens. 2023;37(7):548-553. doi:10.1038/s41371-022-00729-2

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#vitamind #sunlightbenefits