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0:00 - Introduction
0:15 - More Ketones, Sicker Liver
2:25 - Why?
3:55 - How do we apply this?
6:35 - Ketone Supplementation?
7:40 - Main Points

References
[Study 518] Queathem ED, Stagg DB, Nelson AB, et al. Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation. J Clin Invest. 2025;135(12):e191021. doi:10.1172/JCI191021.

Funding/Conflicts: Public Funding [Supported by the US National Institutes of Health — grants DK091538, DK122832, HL166142, DK136772, and AG069781; no public-sector conflicts reported.] // Potential Conflicts of Interest: Peter A. Crawford (PAC) has served as an external consultant for Selah Therapeutics

[A] Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC. Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr. 2011;93(5):1048-1052. doi:10.3945/ajcn.110.007674

[B] Holmer M, Lindqvist C, Petersson S, et al. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet - a randomised controlled trial. JHEP Rep. 2021;3(3):100256. Published 2021 Feb 17. doi:10.1016/j.jhepr.2021.100256

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