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0:00 - Introduction
1:11 - Study Background
2:59 - Plaque in the Arteries
3:48 - Is ApoB linked to Plaque?
4:09 - Plaque begets Plaque
5:01 - Corrections and Critiques
5:53 - Pre-Registration Critique and Unreported Outcomes
7:51 - Absolute Plaque Growth Critique
17:38 - Lack of ApoB association Critique
21:43 - Take-Aways
23:18 - Quick Word of Thanks and Spiders

References
[Study 436] Soto-Mota A, Norwitz NG, Manubolu VS, et al. Plaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial. JACC Adv. Published online March 18, 2025. doi:10.1016/j.jacadv.2025.101686

Funding/Conflicts: Non-Profit Funding [Citizen Science Foundation] // Potential direct Conflicts of Interest [Dr. Nicholas Norwitz is a co-author of a Mediterranean low-carbohydrate diet cookbook. He donates all royalty payments from the book to nutrition research and education; David Feldman has received financial contributions through membership platforms (e.g., Patreon) to support ongoing research and is a partner in Own Your Labs LLC; All other authors reported no conflicts of interest relevant to the contents of the paper.]

Dr. Nicola Guess: https://drguess.substack.com/p/lean-mass-hyper-responders-and-atherosclerosis
Dr. Stanfield: https://www.youtube.com/watch?v=JE1EACWZiWw
Dr. Kevin Klatt: https://kcklatt.substack.com/p/keto-ldl-c-and-lmhr-oh-my
Alex Leaf: https://alexleaf.com/lean-mass-hyper-responders-are-not-protected-from-atherosclerosis/
Dr. Norwitz Rebuttal: https://youtu.be/sv5apthpLGs?si=nth2PH7PectkBG_v
Dr. Budoff Rebuttal: https://youtu.be/lEKFMeg8AmY?si=q4lNADnFtBlQB-Qu

My Original Video: https://youtu.be/U9xSqdzGIXI

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