
Why do we develop plaque in our arteries, but not our veins?
Physionic
29 abr 2024
Mindsip insights from this episode:
Recognize environmental impact on grafted veins to prevent atherosclerosis
When a vein is surgically grafted into the arterial blood supply, it can develop atherosclerosis, suggesting the environment, not just the vein itself, is key.
Understand why veins resist plaque buildup unlike arteries
Despite being exposed to the same amount of LDL cholesterol, veins do not develop the plaque buildup (atherosclerosis) that is seen in arteries.
Manage blood pressure to prevent plaque buildup in arteries
The higher blood pressure in arteries can drastically alter the gene expression of blood vessel cells, causing them to produce more of the proteins that lead to plaque buildup.
Differentiate proteoglycan types to understand LDL attraction in arteries
The specific type of proteoglycan chains (GAGs) most prevalent in arteries has a much greater chemical attraction to LDL than the types found in veins.
Understand LDL retention in arteries due to proteoglycans
Arteries contain much higher amounts of molecules called proteoglycans, which act to retain LDL particles, compared to veins.
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