Anti-Aging Molecule Rapamycin’s Anti-Alzheimer’s Promise: A Mitochondria Story

Physionic

20 nov 2024

Episode description

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0:00 - Introduction
0:42 - Rapamycin's relationship to Alzheimer's Disease
1:36 - Rapamycin's Mitochondria Connection
6:01 - What triggers mitochondrial elimination?
9:20 - How would clearing out mitochondria help?

References
[Study 357] Wang H, Fu J, Xu X, Yang Z, Zhang T. Rapamycin Activates Mitophagy and Alleviates Cognitive and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2021;76(10):1707-1713. doi:10.1093/gerona/glab142

Funding/Conflicts: Public Funding [National Natural Science Foundation of China] // No Conflicts of Interest

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#alzheimerscare #alzheimersprevention #alzheimerawareness

Episode description

Mindsip insights from this episode:

Restore mitochondrial health with rapamycin in Alzheimer's models

The addition of rapamycin was shown to recover a large amount of the mitochondrial membrane potential lost in Alzheimer's disease models.

#mitochondria

#rapamycin

Utilize rapamycin to prevent neuron death by reducing pro-apoptotic proteins

Rapamycin was shown to eliminate the increase of pro-apoptotic proteins like BAX, which would otherwise lead to the death of neurons.

#rapamycin

#regeneration

Target damaged mitochondria for elimination through Parkin activation

A compromised membrane potential in a mitochondrion is a key trigger that attracts destruction enzymes like Parkin to eliminate it.

#mitochondria

#regeneration

Isolate mitochondria to uncover autophagy protein concentration

By isolating mitochondria from the rest of the cell, researchers discovered that key autophagy proteins were concentrated there, a detail missed when analyzing the whole cell.