
Are We Wrong About the Perfect Protein Intake?
Brad Stanfield
28 jul 2025
Mindsip insights from this episode:
Avoid one week of bedrest to preserve muscle mass
Even if you are healthy and eating normally, one week of bedrest can cause the loss of approximately 1.4 kg (over 3 lbs) of muscle mass.
Limit high-protein diets to reduce cancer risk
In adults aged 50-65, a high-protein diet was linked to a 74% higher risk of all-cause mortality and a four-fold increased risk of dying from cancer.
Limit animal protein to improve health outcomes
The negative health effects of high protein intake were primarily associated with animal protein, whereas plant-based protein was not found to be a problem.
Increase protein intake after 65 to reduce cancer risk and frailty
After age 65, the negative associations with high protein reverse, and a higher intake becomes beneficial for reducing cancer mortality and frailty.
Understand muscle loss occurs in rapid bursts during inactivity
The 'catabolic crisis model' proposes that we lose muscle not gradually, but in rapid bursts during short periods of inactivity or illness, which we don't fully regain.
Set optimal protein target at 1.2g per kilogram of ideal body weight
After reviewing all the evidence, the speaker recommends a new optimal protein target of 1.2g per kilogram of ideal body weight, which is lower than many popular recommendations.
Increase protein intake to lower mortality in kidney disease
Contrary to common advice, a recent study showed that patients with mild to moderate chronic kidney disease had 33% lower mortality with a higher protein intake.
Incorporate pea protein for cancer prevention and longevity
The speaker personally uses pea protein powder because it is plant-based and low in the amino acid methionine, which has been linked to cancer growth.
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