Can we reverse Atherosclerosis? [Study 241 - 246 Analysis]

Physionic

31 ene 2024

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender
Study, Notes, & Amendments: https://bit.ly/PhysionicReversingAtherosclerosis

0:00 - Introduction
1:22 - Covered Topics
2:25 - Mechanisms of Action
2:30 - Study 241
2:46 - Study 242
2:55 - Study 243
30:47 - Reversing Atherosclerosis through Exercise
30:58 - Study 246
49:08 - General Solutions for Reversing Atherosclerosis
49:15 - Study 241
49:21 - Study 243
51:17 - Conclusions/Take Aways

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#heartdiseaseawereness #heartdiseaseprevention

Episode description

Mindsip insights from this episode:

Understand atherosclerosis formation through LDL and proteoglycans

Atherosclerosis begins when the APOB protein on LDL particles is electrostatically attracted to oppositely charged proteoglycan proteins in the artery wall, causing the LDL to get stuck.

#LDL

#plaque

Measure APOB for comprehensive cardiovascular risk assessment

For a more accurate assessment of cardiovascular risk, it is better to measure APOB in totality, as this single marker accounts for all atherogenic particles, not just LDL.

#APOB

#risk

Implement HIIT to reverse atherosclerosis

A six-month study on individuals with cardiovascular disease found that high-intensity interval training (HIIT) led to a statistically significant decrease in plaque volume compared to a control group.

#HIIT

#plaque

Utilize HDL particles for effective plaque reversal

HDL particles can aid in plaque reversal by picking up cholesterol molecules and crystals directly from the plaque and transporting them back to the liver.

#cholesterol

#plaque

Lower LDL/APOB levels to enable plaque reversal

Plaque reversal is theoretically possible by lowering LDL/APOB levels enough to create a concentration gradient where more lipoproteins leave the plaque than enter it.

#LDL

#plaque

Understand how arteries transform into bone in advanced atherosclerosis

In advanced atherosclerosis, smooth muscle cells can de-differentiate and start acting like bone cells, depositing calcium into the plaque, which is what a CAC score measures.

#artery

#plaque

Recognize LDL's role in plaque formation despite healthy endothelium

Even with a perfectly healthy endothelium, high levels of LDL can still lead to plaque formation as the particles can pass directly through the endothelial cells themselves.