*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:50 - Metabolism Boost, Weight Shenanigans, Oh my!
2:56 - FGF21
6:20 - A Mitochondrial Paradox
11:14 - Context and Applying this Information
12:26 - Main Points

References
[Study 488] Nicolaisen TS, Lyster AE, Sjøberg KA, et al. ​ Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. ​ Nat Metab. Published online March 6, 2025. doi:10.1038/s42255-025-01236-7

Funding/Conflicts of Interest: Mixed Funding [Public: Independent Research Fund Denmark/Medicine to B.K.; European Foundation for the Study of Diabetes (Future Leader Award NNF20SA0066171 to N.K., Lilly award to A.J.R.; Industry: Novo Nordisk Foundation (NNF17OC0029054, NNF20SA0066171, NNF22OC0074110, NNF18CC0034900, NNF23SA0084103); DFG Emmy Noether (KR5166/2 to N.K. ​), DFG BATenergy (TRR 333/1–450149205 to N.K. ​); The Novo Nordisk Foundation Center for Basic Metabolic Research, partially funded by an unconditional donation from the Novo Nordisk Foundation) // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#fgf21 #metabolismboost