Massive New Study shows Niacin and NAD+ cause Heart Disease?? Is this true? [Study 282]

Physionic

26 feb 2024

Episode description

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Reference
[1] [Study 282] Ferrell M, Wang Z, Anderson JT, et al. A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk. Nat Med. 2024;30(2):424-434. doi:10.1038/s41591-023-02793-8

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#niacin #heartdiseaseawereness #heartdiseaseprevention

Episode description

Mindsip insights from this episode:

Monitor niacin byproducts to assess heart risk

A study found that two niacin breakdown products, 2Py and 4Py, are associated with a higher risk of major adverse cardiovascular events, independent of other risk factors.

#heart

#risk

Consider study limitations due to pre-existing heart disease in subjects

The people included in the study most likely already had some form of heart disease, potentially limiting the findings' applicability to the general population.

#heart

#study

Identify genetic deficiency to assess cardiovascular risk

The increased cardiovascular risk may only apply to the minority of people with a deficient ACSMD enzyme, as three-quarters of study participants did not show elevated risk.

#genetics

#risk

Identify 4Py as key factor in inflammation

Experiments suggest that the metabolite 4Py is the real problematic culprit causing inflammation, while 2Py may just be a passive bystander.

#inflammation

Investigate 4Py metabolite's role in inflammation through VCAM1 expression

The metabolite 4Py was shown to cause inflammation by increasing the expression of a protein called VCAM1, which makes immune cells stick to blood vessel walls.

#inflammation

Identify gene mutation linked to harmful metabolite levels

A specific gene, ACSMD, and a single mutation within it are tightly linked to higher levels of the potentially harmful 2Py and 4Py metabolites.

#genetics

Dismiss concerns about niacin and cardiovascular disease

Despite the study's findings, the speaker concludes they are not worried about niacin causing cardiovascular disease, believing the researchers made a mistake in their interpretation.