The Fastest Way to Get Alzheimer’s (Most People Do This Daily) | Dr. Dale Bredesen

Rangan Chatterjee

5 nov 2025

Episode description

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Alzheimer’s disease is something many of us have seen affect our parents or grandparents, and it can feel like one of the most daunting challenges of ageing. But what if the narrative we’ve been told isn’t the whole truth? What if prevention – and even reversal – is possible?

Today, I’m delighted to welcome Dr Dale Bredesen to my Feel Better Live More podcast, a conversation I’ve been looking forward to for many years. An internationally recognised expert in the mechanisms of neurodegenerative diseases, Dale’s career has been guided by a simple idea: that Alzheimer’s as we know it is not just preventable, but reversible. His dedicated pursuit of the science that makes this a reality has placed him at the vanguard of neurological research and led to the discoveries that today underlie the ReCODE Protocol™.

As well as multiple scientific publications, Dale has written about his findings and research in his first book: ‘The End of Alzheimer’s’, and his very latest book The Ageless Brain is a fantastic read about the simple things we can all do to improve the health of our brains today and across the duration of our lives.

In this powerful conversation, we discuss:
● Why Alzheimer’s is not one single disease, but the end result of multiple systems in the body becoming imbalanced.
● The four stages of cognitive decline, and why identifying problems early can be a game-changer for prevention and treatment.
● The role of genetics, including ApoE4, in dementia risk, and why knowing your genetic status can empower you to take action.
● How inflammation, toxins and energy deficits all contribute to brain decline – and what we can do to address them.
● Real-life case studies of people who have improved, even those in the early stages of dementia.
● The seven key lifestyle factors that can protect and optimise brain health at any age, from diet and exercise to sleep, stress and detoxification.

Dale also shares his vision of a future where cognitive decline is no longer seen as an inevitable part of ageing, but as something we can act on early – much like we already do with heart disease or cancer - and this opens the door to simple, everyday steps we can all take to protect our brains.
If you’ve witnessed Alzheimer’s in your family, it’s easy to feel powerless. But as Dale explains, there is much we can do to reduce our risk, support brain health and hold onto the connections and memories that matter most.

#feelbetterlivemore

Connect with Dr Bredesen:
https://www.apollohealthco.com/dr-bredesen/
https://twitter.com/DrDaleBredesen
https://www.facebook.com/drdalebredesen/
https://www.instagram.com/drdalebredesen/

Dr Bredesen’s books:
The End of Alzheimer’s: The First Programme to Prevent and Reverse the Cognitive Decline of Dementia https://amzn.to/47xL2co
The End of Alzheimer's Programme: The Practical Plan to Prevent and Reverse Cognitive Decline at Any Age https://amzn.to/4oVFHTn
The First Survivors of Alzheimer's: How Patients Recovered Life and Hope in Their Own Words https://amzn.to/47BUWtl
The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime https://amzn.to/4qYenpt

#feelbetterlivemore #feelbetterlivemorepodcast
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DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Episode description

Mindsip insights from this episode:

Support brain health before cognitive training

Brain training can further tax a distressed brain, so it's crucial to first provide nutritional and metabolic support before adding cognitive demand through stimulation.

#cognition

#nutrition

Implement Ketoflex 12:3 diet for optimal brain health

The most effective diet for cognitive support is a plant-rich, mildly ketogenic diet called Ketoflex 12:3, which includes at least 12 hours of fasting and no food for 3 hours before bed.

#cognition

#fasting

Understand APOE4 gene's historical benefits to address Alzheimer's risk

The APOE4 gene, a major risk factor for Alzheimer's today, was the primordial human version for 96% of our evolution and was protective in environments with high infection risk and periods of starvation.

#APOE4

#evolution

Intervene early to combat Alzheimer's disease progression

Alzheimer's disease has four stages, and waiting for the final dementia stage is like waiting for cancer to metastasize before treating it; intervention should happen much earlier.

#Alzheimer's

#dementia

Adopt comprehensive strategies to address Alzheimer's decline

Treating Alzheimer's is like patching 36 holes in a roof; a single drug may patch one hole, but a comprehensive approach is needed to address the multiple factors causing the decline.

#Alzheimer's

Utilize blood tests to detect early Alzheimer's stages

Simple blood-based biomarkers like phospho-tau (P-tau), Aβ 42/40 ratio, GFAP, and NFL can detect the earliest, asymptomatic stages of Alzheimer's disease from a simple blood draw.

#Alzheimer's

#blood-test

Implement regular cognoscopy to make Alzheimer's optional

With early and regular testing (like a 'cognoscopy' every five years) and appropriate preventative protocols, developing the dementia stage of Alzheimer's is becoming optional.

#Alzheimer's

#testing

Acknowledge Alzheimer's survivors who sustain cognitive improvement

There are many documented Alzheimer's survivors who have improved their cognition and sustained the improvement, with the first patient treated in 2012 still doing well.

#Alzheimer's

#cognition

Reframe amyloid as protective response in Alzheimer's context

Amyloid, long considered the cause of Alzheimer's, is actually part of a protective response to insults like infections or toxins, and it can be present for over 20 years without compromising cognitive function.

#Alzheimer's

Utilize red light therapy to stimulate brain function

Red light therapy devices, such as those from the company Vielight, can be used to stimulate the brain, typically using a gamma frequency of around 40 Hz.