
The Heart Disease Protein you've Never Heard
Physionic
4 sept 2025
Mindsip insights from this episode:
Reduce cardiovascular risk by losing weight to lower MPO levels
Data from bariatric surgery patients shows that they experience significant drops in MPO levels, suggesting weight loss is a key strategy for reducing this cardiovascular risk factor.
Test myeloperoxidase to assess arterial health
Myeloperoxidase (MPO) is a specific inflammatory marker for arterial health that you can measure through a publicly available blood test.
Reduce myeloperoxidase levels to improve artery function
The enzyme myeloperoxidase (MPO) directly attacks and stiffens your arteries, with higher blood levels of MPO being associated with reduced blood vessel function.
Combat artery damage by managing fat cell health
Fat cells surrounding your blood vessels can release molecules that attract immune cells, which in turn release the damaging MPO enzyme.
Reduce MPO enzyme to enhance adiponectin levels and combat inflammation
The MPO enzyme reprograms fat cells to release less of the beneficial hormone adiponectin, which further contributes to artery stiffening and inflammation.
Manage visceral fat to control MPO levels
Your fat mass, and specifically your visceral fat, is a major determinant of your MPO levels because this inflammatory process originates in the fat tissue.
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