Ben's *Shocking* Self-Experiment With Semaglutide, The Surprising Facts About GLP-1 & Why GLP-1's May Not Be The Big, Scary Drugs You've Been Led To Believe, With Dr. Tyna Moore
Ben Greenfield
Nov 21, 2024
Mindsip insights from this episode:
Utilize GLP-1s to curb addictive behaviors
Beyond just reducing 'food noise,' GLP-1 agonists can also quiet the drive for other addictive behaviors like alcohol, smoking, gambling, and shopping by acting on the brain's reward pathways.
Utilize GLP-1s to support brain health and prevent cognitive decline
GLP-1 agonists are neuroregenerative and can remyelinate nerves, which may help those with mild cognitive decline avoid progression to more severe forms like Alzheimer's.
Investigate 'Ozempic face' and its impact on collagen and tissue repair
Beyond rapid weight loss, 'Ozempic face' could be linked to a dose-dependent inhibition of adipose-derived stem cells, which are crucial for tissue repair and maintaining collagen.
Manage GLP-1 doses to prevent muscle loss
Muscle loss on GLP-1s is not a direct effect of the peptide, which may actually be anabolic, but rather a management issue where doses are too high, crushing appetite and making adequate protein intake impossible.
Take bile support with GLP-1s to enhance digestion
To mitigate gallbladder issues and indigestion when using GLP-1s, it is recommended to co-administer a bile stimulant like TUDCA to support digestion.
Utilize GLP-1 drugs to bypass unresponsive cells for effective treatment
Unlike natural stimulants, GLP-1 agonist drugs like semaglutide are bioidentical mimics that directly bind to GLP-1 receptors, bypassing the need for your own gut's L-cells to produce the hormone.
Address unresponsive L-cells to enhance natural GLP-1 booster effectiveness
Natural GLP-1 stimulating supplements may not work for some people because their L-cells, which produce GLP-1 in the gut, are 'shot' or unresponsive due to aging or inflammation.
Utilize GLP-1s to regenerate pancreas and prevent type 1 diabetes
GLP-1s have a regenerative effect on the pancreas and, if administered early enough, may even prevent the full onset of type 1 diabetes.
Recognize GLP-1s' origins in neurodegeneration for broader health benefits
GLP-1 agonists were originally developed for neurodegenerative issues, and their powerful blood sugar and weight loss effects were discovered serendipitously.
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