Ben's Shocking Self-Experiment With Semaglutide, The Surprising Facts About GLP-1 & Why GLP-1's May Not Be The Big, Scary Drugs You've Been Led To Believe, With Dr. Tyna Moore

Ben Greenfield

Nov 21, 2024

Episode description

All over the Internet, you hear about the risks of using GLP-1 agonists like Ozempic, Wegovy, and Victoza—such as muscle loss, depression, pancreatitis, nausea, vomiting, digestive distress, appetite suppression, and headaches.

Instagram: https://www.instagram.com/drtyna/
Ozempic Uncovered Course: https://www.drtyna.com/ozempicuncovered

…but it turns out there’s a lot more to the story, including potential systemwide benefits that go far beyond appetite control and weight loss, and fewer side effects than the fearmongering suggests (which I myself have been guilty of!).

The effects of my experiment with GLP-1 agonist semaglutide, how dosage impacts appetite and metabolism, and the importance of individualized strategies for balancing appetite control, blood sugar, and sleep quality…05:54
The cautious use of GLP-1 agonists, their powerful effects on appetite and cognitive health, and the importance of personalized dosing for cognitive and neuroprotective benefits…12:26
How GLP-1 agonists can help brain health and diabetes by improving metabolism, the importance of careful dosing, and why personalized approaches based on individual health needs are the key…18:13
How GLP-1 drugs can support health beyond just weight loss by mimicking natural GLP-1, the potential to restore L-cell function through lifestyle changes, and the importance of individualized, low-dose strategies to avoid side effects…27:04
GLP-1 agonist side effects, from nausea to more serious concerns like gastroparesis, and how careful, individualized dosing and digestive support can minimize risks while still providing therapeutic benefits…38:12
The nuanced risks of GLP-1 drugs, why appetite suppression may dampen life’s pleasures, and the importance of addressing mental health, coping mechanisms, and individualized screening to prevent unintended emotional side effects…45:32
The complex effects of GLP-1 drugs on muscle and tissue health, the risks of improper dosing, and the role of patient compliance with strength trai

Episode description

Instagram: https://www.instagram.com/drtyna/
Ozempic Uncovered Course: https://www.drtyna.com/ozempicuncovered

The effects of my experiment with GLP-1 agonist semaglutide, how dosage impacts appetite and metabolism, and the importance of individualized strategies for balancing appetite control, blood sugar, and sleep quality…05:54
The cautious use of GLP-1 agonists, their powerful effects on appetite and cognitive health, and the importance of personalized dosing for cognitive and neuroprotective benefits…12:26
How GLP-1 agonists can help brain health and diabetes by improving metabolism, the importance of careful dosing, and why personalized approaches based on individual health needs are the key…18:13
How GLP-1 drugs can support health beyond just weight loss by mimicking natural GLP-1, the potential to restore L-cell function through lifestyle changes, and the importance of individualized, low-dose strategies to avoid side effects…27:04
GLP-1 agonist side effects, from nausea to more serious concerns like gastroparesis, and how careful, individualized dosing and digestive support can minimize risks while still providing therapeutic benefits…38:12
The nuanced risks of GLP-1 drugs, why appetite suppression may dampen life’s pleasures, and the importance of addressing mental health, coping mechanisms, and individualized screening to prevent unintended emotional side effects…45:32
The complex effects of GLP-1 drugs on muscle and tissue health, the risks of improper dosing, and the role of patient compliance with strength trai

Mindsip insights from this episode:

Utilize GLP-1s to curb addictive behaviors

Beyond just reducing 'food noise,' GLP-1 agonists can also quiet the drive for other addictive behaviors like alcohol, smoking, gambling, and shopping by acting on the brain's reward pathways.

#addiction

#GLP1

Utilize GLP-1s to support brain health and prevent cognitive decline

GLP-1 agonists are neuroregenerative and can remyelinate nerves, which may help those with mild cognitive decline avoid progression to more severe forms like Alzheimer's.

#Alzheimer's

#GLP1

Investigate 'Ozempic face' and its impact on collagen and tissue repair

Beyond rapid weight loss, 'Ozempic face' could be linked to a dose-dependent inhibition of adipose-derived stem cells, which are crucial for tissue repair and maintaining collagen.

#GLP1

#stem-cell

Manage GLP-1 doses to prevent muscle loss

Muscle loss on GLP-1s is not a direct effect of the peptide, which may actually be anabolic, but rather a management issue where doses are too high, crushing appetite and making adequate protein intake impossible.

#GLP1

#muscle

Take bile support with GLP-1s to enhance digestion

To mitigate gallbladder issues and indigestion when using GLP-1s, it is recommended to co-administer a bile stimulant like TUDCA to support digestion.

#digestion

#GLP1

Utilize GLP-1 drugs to bypass unresponsive cells for effective treatment

Unlike natural stimulants, GLP-1 agonist drugs like semaglutide are bioidentical mimics that directly bind to GLP-1 receptors, bypassing the need for your own gut's L-cells to produce the hormone.

#GLP1

#semaglutide

Address unresponsive L-cells to enhance natural GLP-1 booster effectiveness

Natural GLP-1 stimulating supplements may not work for some people because their L-cells, which produce GLP-1 in the gut, are 'shot' or unresponsive due to aging or inflammation.

#GLP1

#gut

Utilize GLP-1s to regenerate pancreas and prevent type 1 diabetes

GLP-1s have a regenerative effect on the pancreas and, if administered early enough, may even prevent the full onset of type 1 diabetes.

#GLP1

#regeneration

Recognize GLP-1s' origins in neurodegeneration for broader health benefits

GLP-1 agonists were originally developed for neurodegenerative issues, and their powerful blood sugar and weight loss effects were discovered serendipitously.