Anti-Aging Secrets Of The World's Longest-Lived Woman, The Top Longevity "Drugs", Fat Loss & Muscle Gain Tips & Much More! Q&A 494

Ben Greenfield

30 oct 2025

Episode description

Full Show Notes: https://bengreenfieldlife.com/494

In this episode, I dig into the fascinating story of the world’s oldest woman—a vibrant supercentenarian from Spain who made it to 117 years old. I break down what researchers discovered about her genes, lifestyle, and daily habits (you might be surprised by some of the things she ate and didn’t do!).

I also get nerdy about the newest longevity drugs and supplements—like curcumin, spermidine, taurine, and a few others you might not expect—and explain which ones actually work, according to the science in mammals. Plus, I share some updates from my own life, like the weirdly exciting health setting I just found on my new iPhone, and spill the beans on why I microdose alcohol (and sometimes other things) instead of going on a bender.

If you’re curious about muscle gain (do you really need to be in a calorie surplus?), soft-shell vs hardshell hyperbaric chambers, or how certain supplements might actually help you live longer, you’re in the right place. There’s a lot of info coming your way, and I’ve tried to translate all the geeky science into practical tips for you to use.

Episode Sponsors:

Health Lighting: If you want to see and feel the difference better light can make in your life, give Chromalux® full spectrum light bulbs a try. Go to healthlighting.com and use code Ben10 at checkout to save 10% off your order.

Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at Sunlighten.com/BEN with code BEN.

IM8: Ditch the cabinet full of supplements—IM8 packs 92 powerhouse ingredients into one delicious scoop for all-day energy, gut health, and cellular support. Go to IM8Health.com and use code BEN for an exclusive gift—fuel your body the right way!

Gameday Men’s Health: Gameday Men's Health offers science-backed, physician-led men's health optimization with personalized protocols for testosterone, peptide therapy, ED treatment, and more—helping you perform at your best whether you're training hard or keeping up with life. Visit gamedaymenshealth.com/bengreenfield for a free testosterone test and consultation at a clinic near you.

LMNT: Everyone needs electrolytes, especially thos

Episode description

Full Show Notes: https://bengreenfieldlife.com/494

Episode Sponsors:

LMNT: Everyone needs electrolytes, especially thos

Mindsip insights from this episode:

Microdose GLP-1 to reduce neuroinflammation and food noise

The host microdoses the GLP-1 drug Retatrutide not for weight loss, but to quiet 'food noise' and reduce neuroinflammation.

#GLP1

#microdosing

Select hyperbaric chamber based on inflammation type

Soft-shell hyperbaric chambers are more effective for chronic inflammation (TNF-alpha, IL-6), while hard-shell chambers are better for cardiovascular inflammation (myeloperoxidase).

#hyperbaric

#inflammation

Beware statins for potential GLP-1 reduction and insulin resistance

Recent research in Cell Metabolism shows statins can worsen insulin resistance by reducing the body's natural levels of the hormone GLP-1.

#GLP1

#statin

Disable PWM on iPhone 17 to reduce eye strain

The new iPhone 17 has a setting to disable pulse width modulation (PWM), which can reduce screen flicker and associated eye strain or headaches.

#screen-time

Prioritize telomere shortening rate over length for longevity insights

The world's oldest woman had short telomeres, suggesting the rate of shortening is a more important longevity metric than their absolute length.

#longevity

#telomeres

Implement peptide protocol with Epitalon to elongate telomeres

The peptide Epitalon, identified as a top anti-aging compound, is used in a 10-day course twice a year to help elongate telomeres.

#anti-aging

#peptides

Recognize high LDL cholesterol as potential protective factor

The world's longest-living woman had high LDL cholesterol, which may have been protective in the absence of other risk factors like inflammation or high blood glucose.

#LDL

#longevity

Build muscle in a calorie deficit with high protein intake

It is possible to build muscle while in a calorie deficit as long as protein intake is high, debunking the myth that you must eat a surplus to gain muscle.