Does Glycine extend Lifespan? [Study 297 Study Analysis]

Physionic

12 jun 2024

Episode description

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Studies, Notes, & Amendments: https://bit.ly/GlycineLongevity

0:00 – Introduction
00:45 – Topics Covered
01:50 – Mechanism of Action
11:39 – Glycine and Life Extension
11:51 – Study 297
12:23 – Study Design
19:10 – Glycine and Lifespan Data [How to Read the Data]
26:59 – Mid-Point Conclusions

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The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

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#glycine #longevity

Episode description

Mindsip insights from this episode:

Recognize sex-specific lifespan gains from glycine

The median lifespan increase from glycine was more pronounced in male mice at 6.2% compared to female mice at 3.7%.

#lifespan

Utilize glycine supplementation to extend lifespan

In a large, multi-lab study, glycine supplementation was shown to significantly extend the lifespan of mice, indicated by a rightward shift in the survival curve.

#longevity

#supplement

Leverage robust mouse study findings for reliable insights

The study's findings are particularly strong because it used genetically diverse mice and was replicated independently across three different labs simultaneously.

#research

#study

Utilize glycine to stabilize immune cells and reduce inflammation

Glycine may reduce chronic inflammation by binding to chloride channels on immune cells, making them more stable and less likely to become pro-inflammatory.

#inflammation

#supplement

Incorporate glycine to inhibit mTOR pathway and promote longevity

Glycine may promote longevity by binding with the amino acid methionine, preventing it from activating the mTOR pathway which is linked to aging and cell growth.