Eat THESE Anti-Aging Mushrooms to Live Longer (Paul Stamets)

Dave Asprey

12 sept 2025

Episode description

Want to biohack your biology with nature’s most powerful anti-aging compounds? In this episode, you’ll discover how medicinal mushrooms fuel neurogenesis, protect mitochondria, supercharge immunity, and even help save the planet’s pollinators. From sharper focus and deeper REM sleep to protecting DNA from oxidative stress, fungi are the ultimate biohacking tools for performance, resilience, and longevity. 



Watch episodes on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 



(Re-run) Host Dave Asprey sits down with legendary mycologist and author Paul Stamets and mushroom entrepreneur Julian Mitchell. Together, they uncover the science of fungi as medicine — how mushrooms repair nerves, fight viruses, act as prebiotics for your microbiome, and provide the ultimate anti-aging biohacks. You’ll also hear how fungi hold the key to saving pollinators, regenerating soil, and extending human longevity. 



You’ll Learn: 

• Which anti-aging compounds in mushrooms protect your mitochondria and DNA 

• How lion’s mane stimulates nerve growth factor and improves memory, focus, and REM sleep 

• Why oyster mushrooms may help fight flu viruses and reduce chronic inflammation 

• How mushroom tinctures unlock more bioactive compounds than powders or capsules 

• The surprising role fungi play in saving bees and restoring environmental balance 



Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 



Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 



Keywords: anti-aging mushrooms, Paul Stamets fungi, lion’s mane memory, mushroom tincture benefits, ergothionine mitochondrial protection, oyster mushroom flu prevention, reishi immune system, cordyceps endurance, turkey tail microbiome, medicinal mushroom research, fungi save the bees, chaga antioxidants, mushroom longevity biohack, mycelium networks, functional mushrooms anti-inflammatory, mushroom brain health, neurogenesis fungi, adaptogenic mushrooms, mushroom cooking bioavailability 



• Lifecykel Mushroom Products - use code ‘DAVE20’ for 20% off:

Episode description

Want to biohack your biology with nature’s most powerful anti-aging compounds? In this episode, you’ll discover how medicinal mushrooms fuel neurogenesis, protect mitochondria, supercharge immunity, and even help save the planet’s pollinators. From sharper focus and deeper REM sleep to protecting DNA from oxidative stress, fungi are the ultimate biohacking tools for performance, resilience, and longevity. 



Watch episodes on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 



(Re-run) Host Dave Asprey sits down with legendary mycologist and author Paul Stamets and mushroom entrepreneur Julian Mitchell. Together, they uncover the science of fungi as medicine — how mushrooms repair nerves, fight viruses, act as prebiotics for your microbiome, and provide the ultimate anti-aging biohacks. You’ll also hear how fungi hold the key to saving pollinators, regenerating soil, and extending human longevity. 



You’ll Learn: 

• Which anti-aging compounds in mushrooms protect your mitochondria and DNA 

• How lion’s mane stimulates nerve growth factor and improves memory, focus, and REM sleep 

• Why oyster mushrooms may help fight flu viruses and reduce chronic inflammation 

• How mushroom tinctures unlock more bioactive compounds than powders or capsules 

• The surprising role fungi play in saving bees and restoring environmental balance 



Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 



Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 



Keywords: anti-aging mushrooms, Paul Stamets fungi, lion’s mane memory, mushroom tincture benefits, ergothionine mitochondrial protection, oyster mushroom flu prevention, reishi immune system, cordyceps endurance, turkey tail microbiome, medicinal mushroom research, fungi save the bees, chaga antioxidants, mushroom longevity biohack, mycelium networks, functional mushrooms anti-inflammatory, mushroom brain health, neurogenesis fungi, adaptogenic mushrooms, mushroom cooking bioavailability 



• Lifecykel Mushroom Products - use code ‘DAVE20’ for 20% off:

Mindsip insights from this episode:

Implement cyclical pulse therapy for effective psilocybin use

Frequent, high-dose use of psilocybin is not recommended; a cyclical approach of stimulation and rest makes the experience fresher and more effective.

Utilize mycelium extracts for superior antiviral effects

In government-sponsored lab tests, diluted mycelium extracts showed more potent antiviral activity than two well-known pharmaceutical drugs.

Cook mushrooms on high flame to maximize ergothioneine

To maximize the antioxidant ergothioneine, cook mushrooms on a preheated pan with water on a high flame for a couple of minutes.

Utilize lightning to double mushroom yield

Japanese researchers found that zapping mushroom logs with 50,000 volts of electricity can double the yield, confirming ancient folklore.

Recognize our mycelial heritage as descendants of fungi

We are considered mycelial beings who descended from fungi, our ancestors, which first formed networks on Earth.

Amplify mushroom benefits with Kakadu plum's vitamin C

The Kakadu plum, with 100 times the vitamin C of an orange, is added to some mushroom extracts to heighten and amplify their benefits.

Understand mushroom aversion as a microbiome response

A queasy feeling or dislike for mushrooms may be a scientific observation that your microbiome is incompatible with them as a prebiotic.

Grow oyster mushrooms under blue light to enhance flu-fighting properties

Growing oyster mushrooms under blue light can increase the flu-inhibiting compound shikimic acid by 200-fold.

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© Mindsip 2025 – Made with ❤ in Vilnius

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© Mindsip 2025 – Made with ❤ in Vilnius