
How Cancer hijacks your Mitochondria [Study 284]
Physionic
17 abr 2024
Mindsip insights from this episode:
Understand how cancer cells deactivate immune response through theft
A less obvious reason for the theft is that by draining immune cells of their mitochondria, cancer cells deactivate them and evade the body's immune response.
Package mitochondria in exocyst complexes for targeted delivery
Mitochondria are packaged into special vesicles called exocysts complexes before being sent across the nanotube from the immune cell to the cancer cell.
Understand cancer cell tentacles to enhance immune response
Cancer cells extend long nanotubes, like tentacles, to physically connect with the immune cells that are trying to kill them.
Understand how stolen mitochondria drive cancer growth
One reason cancer cells steal mitochondria is to increase their own energy production, which is measured by oxygen consumption, to fuel their growth and survival.
Utilize drug L778123 to enhance immune response against tumors
In a mouse study, a drug that inhibits nanotube formation (L778123) showed it could help more immune cells invade and attack the tumor.
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