Mangoes: Protecting against Neurodegenerative Disease… with a Twist.

Physionic

13 sept 2025

Episode description

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0:00 - Introduction
2:10 - I've got Mangoes on the Brain
5:04 - The Twist...
6:29 - Main Points

References
[Study 516] Nong W, Chen X, Chen Y, et al. Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation. IBRO Neuroscience Reports. 2025;18:574-591. doi:10.1016/j.ibneur.2025.04.006.

[A] Wightman EL, Jackson PA, Forster J, et al. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients. 2020;12(8):2194. Published 2020 Jul 23. doi:10.3390/nu12082194

[B] Jeyakodi S, Krishnakumar A, Dalal M, Shetty BS. Assessment of efficacy and safety of Mangifera indica extract (Stadice®) for cognitive function: a randomized, double-blind, placebo-controlled study. Cureus. 2024;16(7):e65751. doi:10.7759/cureus.65751

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#brainhealth #brainfoods #brainfood

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
2:10 - I've got Mangoes on the Brain
5:04 - The Twist...
6:29 - Main Points

References
[Study 516] Nong W, Chen X, Chen Y, et al. Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation. IBRO Neuroscience Reports. 2025;18:574-591. doi:10.1016/j.ibneur.2025.04.006.

[A] Wightman EL, Jackson PA, Forster J, et al. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients. 2020;12(8):2194. Published 2020 Jul 23. doi:10.3390/nu12082194

[B] Jeyakodi S, Krishnakumar A, Dalal M, Shetty BS. Assessment of efficacy and safety of Mangifera indica extract (Stadice®) for cognitive function: a randomized, double-blind, placebo-controlled study. Cureus. 2024;16(7):e65751. doi:10.7759/cureus.65751

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#brainhealth #brainfoods #brainfood

Mindsip insights from this episode:

Utilize mango molecule magnafarin to combat brain aging

A molecule found in mangoes, called magnafarin, reduces neuroinflammation and cellular senescence in the brain's immune cells.

Acknowledge small cognitive boost from magnafarin trials

Human trials on magnafarin show a cognitive boosting benefit, but the effect size is quite small and the studies are mostly short-term.

Utilize magnafarin from mangoes to combat Alzheimer's plaques

In cell studies, magnafarin significantly reduces the inflammation caused by the buildup of plaques associated with diseases like Alzheimer's.

Question industry bias in magnafarin research findings

All of the human studies on magnafarin that the speaker could find were industry-associated, suggesting a potential for bias in the results.

Enjoy mangoes as an effortless health boost

The speaker concludes that the effect is not big enough to go out of your way for mangoes, but they are an easy win if you already like them.

Exercise caution with high doses of mango leaves

Despite their potency, one should be cautious with high doses from mango leaves as they have not been properly vetted in long-term trials.

Utilize mango leaves for higher magnafarin concentration

Mango leaves and peel contain significantly more magnafarin than the fruit, with leaves having anywhere from 5 to 50 times the concentration.

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