Everything You Need To Know About Testosterone Replacement Therapy & Hormone Optimization, With Gameday's Dr. Evan Miller
Ben Greenfield
Aug 2, 2025
Mindsip insights from this episode:
Request Certificate of Analysis to verify compounding pharmacy quality
When using a compounding pharmacy, you should request their Certificate of Analysis (COA) to ensure quality, and be wary if they refuse to provide it.
Identify low testosterone symptoms to avoid misdiagnosis as depression
The symptoms of low testosterone—low energy, poor mood, and poor sleep—are often misdiagnosed as depression, leading to incorrect treatment with antidepressants.
Recognize poor sleep as key indicator of low testosterone
The most common and 'safest' symptom men report for low testosterone is poor sleep, not erectile dysfunction or low libido.
Cycle off TRT to restore fertility with Clomid
Men on testosterone can cycle off and use medications like Clomid to restore natural production and fertility, then resume TRT later.
Boost growth hormone and improve sleep with Sermorelin
The peptide Sermorelin is considered the 'hottest peptide right now' for boosting growth hormone, with its most noticeable effect being significantly improved sleep.
Consume high fat with oral testosterone for effective absorption
Oral testosterone pills, like Kisotrex, require consumption of significant amounts of fat to be properly absorbed and effective.
Increase lab testing frequency for effective TRT management
Standard six-month lab testing for TRT is insufficient; more frequent checks are crucial for compliance, safety, and ensuring the patient feels better.
Manage blood thickness on TRT with hydration and dosage adjustments
To manage the common TRT side effect of thickened blood, one can ensure proper hydration, take grapefruit seed extract, or split the weekly injection into two smaller doses.
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