Everything You Need To Know About Testosterone Replacement Therapy & Hormone Optimization, With Gameday's Dr. Evan Miller

Ben Greenfield

Aug 2, 2025

Episode description

Evan Miller, Ph.D., is the visionary founder and CEO of Gameday Men's Health, a premier men’s health clinic dedicated to empowering men to optimize their well-being and performance.

Today, Dr. Miller is widely regarded as a trailblazer in men’s wellness, leading a brand that continues to revolutionize how men approach their health, performance, and vitality.

Full show notes: https://bengreenfieldlife.com/gamedaypodcast

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Mindsip insights from this episode:

Request Certificate of Analysis to verify compounding pharmacy quality

When using a compounding pharmacy, you should request their Certificate of Analysis (COA) to ensure quality, and be wary if they refuse to provide it.

#compounding

#safety

Identify low testosterone symptoms to avoid misdiagnosis as depression

The symptoms of low testosterone—low energy, poor mood, and poor sleep—are often misdiagnosed as depression, leading to incorrect treatment with antidepressants.

#depression

#testosterone

Recognize poor sleep as key indicator of low testosterone

The most common and 'safest' symptom men report for low testosterone is poor sleep, not erectile dysfunction or low libido.

#sleep

#testosterone

Cycle off TRT to restore fertility with Clomid

Men on testosterone can cycle off and use medications like Clomid to restore natural production and fertility, then resume TRT later.

#fertility

#TRT

Boost growth hormone and improve sleep with Sermorelin

The peptide Sermorelin is considered the 'hottest peptide right now' for boosting growth hormone, with its most noticeable effect being significantly improved sleep.

#peptides

#sleep

Consume high fat with oral testosterone for effective absorption

Oral testosterone pills, like Kisotrex, require consumption of significant amounts of fat to be properly absorbed and effective.

#fat

#testosterone

Increase lab testing frequency for effective TRT management

Standard six-month lab testing for TRT is insufficient; more frequent checks are crucial for compliance, safety, and ensuring the patient feels better.

#testing

#TRT

Manage blood thickness on TRT with hydration and dosage adjustments

To manage the common TRT side effect of thickened blood, one can ensure proper hydration, take grapefruit seed extract, or split the weekly injection into two smaller doses.