Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira

Dave Asprey

Apr 11, 2025

Episode description

If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong?

For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cellular dysfunction? And what if we could change that?

In this episode, Dave Asprey uncovers the cellular biology of hair thinning with longevity researcher Carolina Reis Oliveira. You’ll learn how senescent cells (aka zombie cells) hijack your scalp, disrupt follicle function, and silently accelerate hair loss—and how a breakthrough peptide might stop it cold.

Carolina reveals brand-new clinical research on OS-01, a molecule shown to increase hair density by 40% in just 6 months. But this isn’t a product pitch—it’s a paradigm shift. Together, they explore the hidden drivers of hair aging, from hormone shifts and stress cascades to microbiome imbalances and inflammation, plus the real science behind what can actually regrow hair.

What You’ll Learn in This Episode:

• How “zombie cells” (senescent cells) sabotage your hair from the inside out

• The science behind the OS-01 peptide and how it reverses visible hair thinning

• Why thinning hair isn’t just genetic—and what else is driving it

• How stress, hormones, and aging collide to trigger follicle dysfunction

• What your scalp microbiome has to do with regrowth and hair density

• How to stack red light, peptides, and topicals for real, measurable results

***Visit oneskin.co/DAVE and use code DAVE for and additional 15% off.***

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• OneSkin Instagram – https://www.instagram.com/oneskin.co/

• OneSkin Website: https://www.oneskin.co/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave

Episode description

If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong?

What You’ll Learn in This Episode:

• How “zombie cells” (senescent cells) sabotage your hair from the inside out

• The science behind the OS-01 peptide and how it reverses visible hair thinning

• Why thinning hair isn’t just genetic—and what else is driving it

• How stress, hormones, and aging collide to trigger follicle dysfunction

• What your scalp microbiome has to do with regrowth and hair density

• How to stack red light, peptides, and topicals for real, measurable results

***Visit oneskin.co/DAVE and use code DAVE for and additional 15% off.***

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• OneSkin Instagram – https://www.instagram.com/oneskin.co/

• OneSkin Website: https://www.oneskin.co/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave

Mindsip insights from this episode:

Balance scalp microbiome with prebiotics to promote hair growth

The scalp has its own microbiome, and using a prebiotic can shift the balance from hair-loss-related bacteria to bacteria that promote hair growth.

#hair-loss

#microbiome

Manage stress to prevent hair loss from CRH hormone

The stress-related hormone CRH can induce senescence, or 'zombie cells,' in hair follicles, which is a direct mechanism for stress-associated hair loss.

#hair-loss

#stress

Understand finasteride's nine-month libido recovery timeline

After only a brief topical use of a finasteride-like drug for hair loss, it took nine months for normal libido to return.

#hair-loss

#side-effects

Achieve 40% more hair density with OS1 peptide product

In a six-month clinical trial, the OS1 peptide hair product led to an average 40% increase in hair density for over 86% of participants.

#hair-loss

#peptides

Stack OS1 peptide with minoxidil and red light therapy for enhanced hair treatment

It is safe and potentially more effective to combine, or 'stack,' the OS1 peptide product with other treatments like minoxidil and red light therapy.

#peptides

#red-light

Utilize coffee to protect hair follicle stem cells

Polyphenols and chlorogenic acid found in coffee can protect hair follicle stem cells, while topical caffeine can reduce DHT in the scalp.

#hair-loss

#stem-cell

Address copper depletion to combat post-pregnancy hair loss

A potential and often overlooked cause of post-pregnancy hair loss is the depletion of copper, which is lost when the placenta is expelled.

#copper

#hair-loss

Target senescent cells locally to prevent unwanted hair growth

Unlike some treatments, the OS1 peptide targets senescent cells locally, so it won't cause unwanted hair growth on your face or back.

#peptides

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