What's The Difference Between A HEALTHY Gut & A Gut "Missing" Key Beneficial Bacterial Strains? (& How To Fast-Track Your Gut Back To Balance) With Dr. Adam Perlman

Ben Greenfield

Oct 19, 2024

Episode description

In this episode, you'll get to discover the fascinating world of gut health with Dr. Adam Perlman, Chief Medical Officer at Pendulum Therapeutics. You’ll explore how high-fiber, polyphenol-rich foods boost beneficial bacteria like Akkermansia, which support gut health and enhance athletic performance by maintaining gut lining integrity. Dr. Perlman also shares insights from his integrative medicine career, revealing practical tips to keep your microbiome strong in modern life, from polyphenol supplements to the synergy of probiotic strains. We’ll also dig into cutting-edge research on GLP-1 triggering probiotics for metabolic health, how diet and exercise play crucial roles in overall wellness, and much more!

For more insights on Pendulum's innovative work, check out my podcast with their co-founder, Dr. Colleen Cutcliffe, here.

For Full Show Notes: https://bengreenfieldlife.com/glp1podcast

Episode Sponsors: 

Joovv: Go to Joovv.com/ben and apply code BEN for an exclusive discount.

BIOptimizers Mushroom Breakthrough: Go to bioptimizers.com/ben now and enter promo code BEN10 to get 10% off any order.

Hiya: Go to hiyahealth.com/BEN for 50% your first order.

Apollo: Head over to apolloneuro.com/bengreenfield and use code bengreenfield for $60 off.

Timeline Nutrition: Go to timelinenutrition.com/BEN and use code BEN to get 10% off your order.

See omnystudio.com/listener for privacy information.

Episode description

In this episode, you'll get to discover the fascinating world of gut health with Dr. Adam Perlman, Chief Medical Officer at Pendulum Therapeutics. You’ll explore how high-fiber, polyphenol-rich foods boost beneficial bacteria like Akkermansia, which support gut health and enhance athletic performance by maintaining gut lining integrity. Dr. Perlman also shares insights from his integrative medicine career, revealing practical tips to keep your microbiome strong in modern life, from polyphenol supplements to the synergy of probiotic strains. We’ll also dig into cutting-edge research on GLP-1 triggering probiotics for metabolic health, how diet and exercise play crucial roles in overall wellness, and much more!

For more insights on Pendulum's innovative work, check out my podcast with their co-founder, Dr. Colleen Cutcliffe, here.

For Full Show Notes: https://bengreenfieldlife.com/glp1podcast

Episode Sponsors: 

Joovv: Go to Joovv.com/ben and apply code BEN for an exclusive discount.

BIOptimizers Mushroom Breakthrough: Go to bioptimizers.com/ben now and enter promo code BEN10 to get 10% off any order.

Hiya: Go to hiyahealth.com/BEN for 50% your first order.

Apollo: Head over to apolloneuro.com/bengreenfield and use code bengreenfield for $60 off.

Timeline Nutrition: Go to timelinenutrition.com/BEN and use code BEN to get 10% off your order.

See omnystudio.com/listener for privacy information.

Mindsip insights from this episode:

Choose GLP-1 drugs cautiously due to stronger side effects than probiotics

GLP-1 agonist drugs are about 100 times stronger than probiotics that stimulate GLP-1, which is why the drugs have more side effects like nausea and muscle loss.

Boost Akkermansia levels for enhanced longevity

Studies show an association between higher levels of Akkermansia and individuals who live the longest in good health.

Address microbiome shifts to ease post-pregnancy weight loss

Shifts in the gut microbiome during pregnancy to absorb more calories can fail to revert, potentially making post-pregnancy weight loss difficult.

Utilize GLP-1 probiotic trio to enhance natural release

The combination of Akkermansia muciniphila, Clostridium butyricum, and Bifidobacterium infantus works synergistically to support the body's natural release of GLP-1.

Boost Akkermansia levels to enhance butyrate production

Low levels of the gut bacteria Akkermansia are directly linked to low levels of the short-chain fatty acid butyrate, which is a fuel for gut cells.

Preserve anaerobic probiotics by keeping capsules intact

Pendulum's probiotics are housed in an acid-resistant, delayed-release capsule to protect the anaerobic bacteria, so you should not break it open into a smoothie.

Enhance glucose control with Pendulum probiotic alongside metformin

In a study, the Pendulum Glucose Control probiotic reduced glucose spikes by 33% even in patients who were already taking metformin.

Boost Akkermansia levels with polyphenol consumption

You can specifically increase your levels of Akkermansia by consuming polyphenols, which is why Pendulum offers a polyphenol booster product.

Support gut health with Akkermansia to heal leaky gut

Akkermansia helps maintain the gut lining by consuming degraded mucin and stimulating cells to produce fresh mucin, which can help with leaky gut.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius