Discover how decoding your DNA can unlock the full potential of plant medicine. This episode delivers a cannabis masterclass for biohackers, revealing how personalized genetics are transforming human performance, brain optimization, and longevity. You’ll learn how to identify your ideal cannabis and supplement protocols, balance your endocannabinoid system, and turn precision data into powerful healing. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Len May, MSc, visionary authority in personalized medicine and CEO of EndoDNA, the world leader in DNA-based wellness technology. With over 25 years of pioneering work in genomics, epigenetics, and medicinal cannabis, Len’s patented DNA decoding system maps your unique genotypes to design tailor-made health solutions. His company holds the world’s largest real-world efficacy database in precision wellness, integrating functional medicine, AI-driven analytics, and genetic data to create personalized blueprints for optimal brain function and performance. 

Together, Dave and Len explore how your genetic code determines how you respond to cannabis, psychedelics, nootropics, and supplements—and how to use that data to reduce anxiety, improve sleep optimization, and enhance focus. You’ll learn how decoding your DNA can guide anti-aging strategies, mitochondrial performance, metabolism, and neuroplasticity, revealing new ways to live longer and smarter. 

This episode dives deep into the intersection of cannabis science, genomics, and biohacking. You’ll discover how genetic polymorphisms influence mood, cognition, and stress response, and how personalized medicine can help you make smarter decisions around ketosis, fasting, and recovery. From optimizing the endocannabinoid system to hacking your biology for resilience and longevity, this is the future of functional medicine in action. 

You’ll Learn: 

• How the endocannabinoid system regulates mood, focus, pain, and stress response 

• Which genetic polymorphisms affect cannabis sensitivity, anxiety risk, and dosing windows 

• How to use DNA testing to select cannabinoid and terpene ratios that fit your biology 

• Why delivery method matters and when sublingual dosing outperforms inhalation 

• How personalized cannabis protocols can support sleep optimization, recovery, and emotional regulation 

• The role of cannabinoids in mitochondrial function, neuroplasticity, and cognitive performance 

• How pharmacogenomics reduces antidepressant side effects and improves treatment matching 

• How to screen genetics for safer psychedelic use and avoid adverse reactions 

• What HL