Butter linked to Cancer: Large Studies Reveal the Hidden Cost

Physionic

3 nov 2025

Episode description

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Created with Biorender

Butter on Cancer - Mechanism Video: https://youtu.be/G4eWcMVXe48?si=2Qrs31JNDhAnGXnl

0:00 - Introduction
0:55 - Butter, Cancer, Mortality, Oh My!
10:12 - Main Points/ Key Takeaways

References
[Study 536] Zhang Y, Chadaideh KS, Li Y, et al. Butter and Plant-Based Oils Intake and Mortality. JAMA Intern Med. 2025;185(5):549-560. doi:10.1001/jamainternmed.2025.0205. Published online March 6, 2025.

Funding/Conflicts: Public Funding [Supported by NIH grants (UM1 CA186107, P01 CA87969, R01 HL034594, R01 HL088521, U01 CA176726, U01 HL145386, U01 CA167552, R01 HL35464, R01 HL60712, P30 DK46200, R00 DK119412, R01 AG077489, R01 NR019992); the NIH had no role in study design, data collection/management/analysis, interpretation, manuscript preparation/approval, or the decision to submit; conflicts: Drs Willett and Stampfer reported NIH grants during the conduct of the study.]; Non-profit funding [No non-profit funders are listed as supporting this study; conflicts: Dr Guasch-Ferré reported grants from the Novo Nordisk Foundation (outside the submitted work).]; Industry funding [No industry funders are listed as supporting this study; conflicts: Dr Guasch-Ferré reported grants from the International Nut and Dried Fruit Council (outside the submitted work); no other disclosures were reported.]

[A] Zhang Y, Zhuang P, Wu F, He W, Mao L, Jia W, et al. Cooking oil/fat consumption and deaths from cardiometabolic diseases and other causes: prospective analysis of 521,120 individuals. BMC Med. 2021;19(1):92. doi:10.1186/s12916-021-01961-2.

[B] Jin S, Je Y. Dairy Consumption and Total Cancer and Cancer-Specific Mortality: A Meta-Analysis of Prospective Cohort Studies. Adv Nutr. 2022;13(4):1063-1082. doi:10.1093/advances/nmab135

[C] Lu W, Chen H, Niu Y, Wu H, Xia D, Wu Y. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. Nutr J. 2016;15(1):91. Published 2016 Oct 21. doi:10.1186/s12937-016-0210-9

[D] Kunkemoeller B, Prendeville H, McIntyre C, et al. The source of dietary fat influences anti-tumour immunity in obese mice. Nat Metab. 2025;7(8):1630-1645. doi:10.1038/s42255-025-01330-w

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

Butter on Cancer - Mechanism Video: https://youtu.be/G4eWcMVXe48?si=2Qrs31JNDhAnGXnl

0:00 - Introduction
0:55 - Butter, Cancer, Mortality, Oh My!
10:12 - Main Points/ Key Takeaways

References
[Study 536] Zhang Y, Chadaideh KS, Li Y, et al. Butter and Plant-Based Oils Intake and Mortality. JAMA Intern Med. 2025;185(5):549-560. doi:10.1001/jamainternmed.2025.0205. Published online March 6, 2025.

Funding/Conflicts: Public Funding [Supported by NIH grants (UM1 CA186107, P01 CA87969, R01 HL034594, R01 HL088521, U01 CA176726, U01 HL145386, U01 CA167552, R01 HL35464, R01 HL60712, P30 DK46200, R00 DK119412, R01 AG077489, R01 NR019992); the NIH had no role in study design, data collection/management/analysis, interpretation, manuscript preparation/approval, or the decision to submit; conflicts: Drs Willett and Stampfer reported NIH grants during the conduct of the study.]; Non-profit funding [No non-profit funders are listed as supporting this study; conflicts: Dr Guasch-Ferré reported grants from the Novo Nordisk Foundation (outside the submitted work).]; Industry funding [No industry funders are listed as supporting this study; conflicts: Dr Guasch-Ferré reported grants from the International Nut and Dried Fruit Council (outside the submitted work); no other disclosures were reported.]

[A] Zhang Y, Zhuang P, Wu F, He W, Mao L, Jia W, et al. Cooking oil/fat consumption and deaths from cardiometabolic diseases and other causes: prospective analysis of 521,120 individuals. BMC Med. 2021;19(1):92. doi:10.1186/s12916-021-01961-2.

[B] Jin S, Je Y. Dairy Consumption and Total Cancer and Cancer-Specific Mortality: A Meta-Analysis of Prospective Cohort Studies. Adv Nutr. 2022;13(4):1063-1082. doi:10.1093/advances/nmab135

[C] Lu W, Chen H, Niu Y, Wu H, Xia D, Wu Y. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. Nutr J. 2016;15(1):91. Published 2016 Oct 21. doi:10.1186/s12937-016-0210-9

[D] Kunkemoeller B, Prendeville H, McIntyre C, et al. The source of dietary fat influences anti-tumour immunity in obese mice. Nat Metab. 2025;7(8):1630-1645. doi:10.1038/s42255-025-01330-w

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Limit butter consumption to reduce cancer mortality risk

A 33-year study of over 200,000 people found that the highest butter consumption was linked to an estimated 12% increased risk of dying from cancer.

Limit butter consumption to reduce mortality risk

Even after researchers adjusted for refined bread consumption, the statistical link between adding butter to food and mortality remained.

Use butter wisely to manage mortality risk

Using butter for baking and frying was not associated with increased mortality risk, whereas adding butter directly to food like bread was.

Eliminate trans fats from butter category for accurate health insights

The study's 'total butter' category was contaminated with margarine blends, which contained harmful trans fats during the early data collection period.

Recognize ketogenic diets as unique physiological contexts

These findings on butter do not apply to ketogenic diets, as being in a ketogenic state is an objectively different physiological context.

Address butter's cancer risk in overweight individuals

The negative effects of butter on cancer may be a bigger problem in an 'obesogenic environment,' meaning for overweight individuals.

Understand butter's role in cancer mortality, not occurrence

The data links butter to cancer mortality (dying from it), not cancer occurrence (getting it), suggesting it may only be a detriment once cancer is already present.

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad