Digital Twins: The End of Human Drug Testing for Biohackers

Dave Asprey

9 oct 2025

Episode description

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension.

Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life.

You’ll Learn:

• How digital twins will end human drug testing

• Why AGI could replace doctors and computer jobs within five years

• How AI models immune function, metabolism, and aging

• The role of mitochondria and inflammation in longevity

• How GLP-1 drugs and metformin extend lifespan

• What continuous biological monitoring means for health tracking

• How AI is transforming functional medicine and personalized care

• Why NAD and energy metabolism are key to human performance

They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan.

This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.

This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 int

Episode description

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

You’ll Learn:

• How digital twins will end human drug testing

• Why AGI could replace doctors and computer jobs within five years

• How AI models immune function, metabolism, and aging

• The role of mitochondria and inflammation in longevity

• How GLP-1 drugs and metformin extend lifespan

• What continuous biological monitoring means for health tracking

• How AI is transforming functional medicine and personalized care

• Why NAD and energy metabolism are key to human performance

This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 int

Mindsip insights from this episode:

Stay alive for next decade to reach longevity escape velocity

We will likely reach longevity escape velocity in 10-15 years, so the main goal should be to stay alive for the next decade.

#lifespan

#longevity

Utilize low-dose GLP-1 agonists to enhance lifespan

Low-dose GLP-1 receptor agonists are described as 'miraculous' anti-aging drugs that normalize metabolism, with calculations suggesting they could add 5-10 years to the average lifespan.

#GLP1

#longevity

Question standard lab results for personalized health insights

Standard lab test ranges are not personalized, as evidenced by the fact that 70% of people who have heart attacks have 'normal' cholesterol levels.

#blood-test

#cholesterol

Reconsider college investment in the age of AI

A professor argues that going to college is probably the worst investment of time and money for young people today, as AI makes traditional education obsolete.

#AI

#education

Integrate AI in healthcare to reduce misdiagnoses

An immunologist states it is currently unethical for doctors not to use AI, as it is already better than them and can massively reduce misdiagnoses.

#AI

#healthcare

Re-engineer immune system to reduce chronic inflammation

Our immune system is a poorly engineered legacy system that likely kills more people than it saves through chronic inflammation and overreactions, and should be re-engineered into an 'immune system 2.0'.

#immune-system

#inflammation

Identify exhausted T-cells to combat chronic inflammation in aging

The most problematic cells in aging are likely a type of 'exhausted' T-cell that accumulates to fight chronic viruses like CMV, which then cause damaging chronic inflammation.

#aging

#inflammation

Incorporate metformin and omega-3 for anti-aging benefits

A world-class immunologist personally takes metformin, omega-3, nicotinamide riboside (NR), urolithin A, and low-dose GLP-1 agonists for anti-aging.

#longevity

#supplement

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