Drown Cancer in This Nutrient – And Flip its Kill Switch

Physionic

28 jul 2025

Episode description

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0:00 - Introduction
2:53 - A Nutrient to the Rescue
3:59 - Nutrient that also increases Cancer??
4:40 - Stressing Cancer...
8:22 - Why the Paradox? And, what to do?
13:12 - Main Points

References
[Study 494] Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ. The Warburg effect dictates the mechanism of butyrate‑mediated histone acetylation and cell proliferation. Mol Cell. 2012 Nov 9;48(4):612–626. doi:10.1016/j.molcel.2012.08.033

Funding/Conflicts: Public Funding [This work was supported by grants from the National Cancer Institute (CA127445 and CA129286 to Y.C.) and the American Cancer Society (RSG-09-084-01-MGO to Y.C.)] // No direct Conflicts of Interest

[A] Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 2012;6(2):320-329. doi:10.1038/ismej.2011.109

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Episode description

Mindsip insights from this episode:

Utilize butyrate to target cancer cells directly

Even at low concentrations, butyrate is harmful to cancer cells that rely on sugar because they bypass metabolizing it and it acts directly on their genes.

#cancer

Implement butyrate-centric strategy to combat sugar-fed cancers

While a minority of cancers feed on fat, this butyrate-centric strategy seems useful for the majority of cancers that undergo the Warburg effect and feed on sugar.

#cancer

#metabolism

Boost butyrate production with fiber-rich foods

You can increase butyrate production by eating dietary fiber-rich foods like green bananas, plantains, onions, garlic, and potatoes.

#fiber

#nutrition

Investigate butyrate-producing bacteria in colorectal cancer patients

Human studies have identified that people with colorectal cancer tend to have fewer butyrate-producing bacteria compared to healthy individuals.

#bacteria

#cancer

Boost p53 function with butyrate for cancer defense

Butyrate can increase the stability and DNA-binding ability of the powerful anti-tumor protein p53, enhancing its cancer-fighting function.

#cancer

#microbiome

Utilize butyrate to alter cancer gene expression

Butyrate primarily harms cancer cells not by being a fuel source, but by changing gene expression through a process called histone acetylation.

#cancer

#microbiome

Understand butyrate's dual role in cancer dynamics

The short-chain fat butyrate can stimulate cancer cells at low concentrations but stresses and kills them at high concentrations.

#cancer

#nutrition

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