For Many, Your Own Blood Is Damaging Your Arteries!

Physionic

25 sept 2025

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
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Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

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Created with Biorender

0:00 - Introduction
0:37 - Red Blood Cells attacking your Arteries
4:59 - Take-Aways/Main Points

References
[Study 519] Collado A, Humoud R, Kontidou E, et al. Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes. J Clin Invest. 2025;135(10):e180900. doi:10.1172/JCI180900

Funding/Conflicts: Mixed Funding [Public: Funding was provided by the Swedish Research Council; the Stockholm County Council; and the Karolinska Institute through doctoral and other institutional grants; Non-Profit: Support for this study came from a Novo Nordisk postdoctoral fellowship; the European Foundation for the Study of Diabetes/Novo Nordisk Foundation Future Leaders Award; the Swedish Heart and Lung Foundation; the Knut and Alice Wallenberg Foundation; the Diabetes Research Wellness Foundation; the Foundation for Geriatric Diseases; the Lars Hierta's Memory Foundation; and Tore Nilson's Foundation for Medical Research.] // No direct Conflicts of Interest

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:37 - Red Blood Cells attacking your Arteries
4:59 - Take-Aways/Main Points

References
[Study 519] Collado A, Humoud R, Kontidou E, et al. Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes. J Clin Invest. 2025;135(10):e180900. doi:10.1172/JCI180900

Funding/Conflicts: Mixed Funding [Public: Funding was provided by the Swedish Research Council; the Stockholm County Council; and the Karolinska Institute through doctoral and other institutional grants; Non-Profit: Support for this study came from a Novo Nordisk postdoctoral fellowship; the European Foundation for the Study of Diabetes/Novo Nordisk Foundation Future Leaders Award; the Swedish Heart and Lung Foundation; the Knut and Alice Wallenberg Foundation; the Diabetes Research Wellness Foundation; the Foundation for Geriatric Diseases; the Lars Hierta's Memory Foundation; and Tore Nilson's Foundation for Medical Research.] // No direct Conflicts of Interest

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Reduce arginase levels to prevent artery stiffness

An enzyme called arginase, released from red blood cells, gets into your artery lining and reduces nitric oxide, which causes arteries to stiffen.

Focus on activity level of arginase enzyme for healthier vesicles

The key difference between healthy and unhealthy vesicles is not the amount of the harmful arginase enzyme, but its level of activity.

Recognize harmful effects of red blood cells on arteries

In certain unhealthy states, your own red blood cells release packages called extracellular vesicles that contain substances harmful to your arteries.

Address insulin resistance to combat artery damage

This artery-damaging mechanism from red blood cells is primarily a problem for individuals who are insulin resistant or have type 2 diabetes.

Reverse insulin resistance to restore red blood cell health

By addressing insulin resistance through nutrition and exercise, you can potentially revert your red blood cells to a healthier state that is less damaging to your arteries.

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad

DESCARGA LA APLICACIÓN

Descubre la sabiduría de la longevidad