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0:00 - Introduction
0:30 - Rapamycin's Proposed Anti-Alzheimer's Effects
3:05 - Does Rapamycin work on Alzheimer's Disease?
5:31 - How does Rapamycin achieve these effects?
8:01 - Take-aways
9:05 - Why is autophagy also increased in Alzheimer's Disease?
10:22 - A Twist to the Story...
References
[Study 355] Kaeberlein M, Galvan V. Rapamycin and Alzheimer's disease: Time for a clinical trial?. Sci Transl Med. 2019;11(476):eaar4289. doi:10.1126/scitranslmed.aar4289
Funding/Conflicts: Public Funding [University of Washington, National Institute of Health] // Potential Conflicts of Interest [Scientific Advising for Resterobio Inc.]
[Study 356] Hou SJ, Zhang SX, Li Y, Xu SY. Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy. Clin Interv Aging. 2023;18:1629-1639. Published 2023 Oct 2. doi:10.2147/CIA.S429440
Funding/Conflicts: Public Funding [Shanxi Provincial Health Commission, Doctoral Fund] // No Potential Conflicts of Interest
[Study 357] Wang H, Fu J, Xu X, Yang Z, Zhang T. Rapamycin Activates Mitophagy and Alleviates Cognitive and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2021;76(10):1707-1713. doi:10.1093/gerona/glab142
Funding/Conflicts: Public Funding [National Natural Science Foundation of China] // No Conflicts of Interest
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#alzheimersprevention #alzheimersresearch #alzheimerscare
