The Secret Molecule for Endless Energy | Dr. Andrew Salzman
Dave Asprey
21 feb 2025
Mindsip insights from this episode:
Boost mitochondrial energy to enhance willpower and decision-making
A study on parole boards showed that decision-making fatigue is real, suggesting willpower is directly tied to mitochondrial energy levels which decline throughout the day.
Ensure adequate NAD levels when consuming caffeine
Taking stimulants like caffeine increases your cells' demand for NAD, and doing so without sufficient levels can lead to a relative deficiency and potential harm.
Utilize NAD IVs for cellular health through conversion to precursors
When you receive an NAD IV, your body converts it back into precursors like NMN and NR in the blood so it can enter your cells.
Address leaky gut to prevent NAD depletion and inflammation
The major cause of progressive inflammation and NAD depletion as you age is a leaky gut allowing bacterial endotoxins into the blood, which increases the NAD-destroying enzyme CD38.
Break the vicious cycle of low NAD to improve gut health
Low NAD levels in gut cells cause the gut to become leakier, which increases inflammation and the NAD-destroying enzyme CD38, further lowering NAD in a negative feedback loop.
Treat aging as root cause to combat diseases
Viewing conditions like arthritis, diabetes, and cancer as isolated is a dated '1950s' approach; the modern view is to treat aging itself as the core derangement that spawns these diseases.
Ensure adequate NAD levels for Viagra effectiveness
Viagra won't be effective if you have an NAD deficiency because your body cannot produce the necessary nitric oxide for it to work.
Block NAD depletion with natural botanicals
Natural compounds like resveratrol from red grapes and hydroxytyrosol from olive oil can slow down the activity of the NAD-depleting enzyme CD38.
Initiate interventions in your 20s to combat aging
The aging process doesn't start at 60 but rather in your early 20s, so interventions should begin then to maintain vigor and prevent decline.
