Breakthrough Cuts Heart Disease by 25%
Brad Stanfield
Dec 9, 2025
Episode description
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Timestamps:
00:00 The Mystery of High Cholesterol Levels
01:11 Discovery of NRC1 and PCSK9
02:06 The Impact of PCSK9 on Cholesterol Levels
04:35 The Success of PCSK9 Inhibitors
06:59 The New VESALIUS-CV Trial
09:18 The Development of Oral PCSK9 Inhibitors
11:06 Conclusion & The Importance of Lifestyle Factors
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Here are the links to the research papers referenced in the video:
https://www.jacc.org/doi/10.1016/j.jacc.2012.08.986
https://www.nejm.org/doi/full/10.1056/NEJMoa1615664
https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
https://jamanetwork.com/journals/jama/article-abstract/2841258
Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.
Mindsip insights from this episode:
Leverage PCSK9 gene mutation for heart disease protection
People born with a broken PCSK9 gene have naturally low LDL cholesterol their entire lives and are extraordinarily protected against heart disease.
Utilize evolocumab to prevent first heart attack in high-risk patients
The Vesalius CV trial proved that the PCSK9 inhibitor evolocumab prevents the first cardiovascular event in high-risk patients, reducing incidents by 25%.
Reform delivery methods to enhance PCSK9 inhibitor therapy access
The biggest barrier to widespread use of powerful PCSK9 inhibitor therapy is not biology but the delivery method, as the drugs are expensive injections.
Switch to oral inlicitide for convenient cholesterol management
A new oral pill called inlicitide has been shown to be just as effective as injectable PCSK9 inhibitors, potentially making the therapy more convenient and accessible.
Incorporate psyllium husk to lower cholesterol levels
The speaker includes psyllium husk in their diet as a specific source of fiber that has been shown to lower cholesterol levels.
Utilize PCSK9 inhibitors as a biological cheat code for cholesterol management
PCSK9 inhibitor medications behave exactly like a biological cheat code for lowering stubbornly high LDL cholesterol levels, even for those with statin intolerance.
Incorporate easy exercise to lower blood pressure
There is one specific and 'ridiculously easy' exercise that has been shown to have outsized effects on lowering blood pressure.
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