How Jeff Bland Reversed His Biological Age at 79 (Part 1)

Mark Hyman

May 28, 2025

Episode description

Dr. Jeff Bland has been called the father of Functional Medicine—and for good reason. His groundbreaking work helped shift our understanding of chronic disease and inspired a generation of doctors to look beyond symptoms and toward root causes. On this episode of The Dr. Hyman Show, I sit down with Jeff to talk about what he’s learned from more than 50 years of studying the science of health, aging, and disease prevention.

We explore:

• Why your biology is not predetermined by your genes—and how to unlock your full potential

• What Jeff’s own health journey reveals about inflammation, biomarkers, and aging well

• How what you eat can shape everything from inflammation to longevity

• Long-term disease risk is shaped by what surrounds you—and how your body responds

Tune in for an insightful conversation with one of my greatest mentors—and discover how science, curiosity, and personal agency can help you live a longer, healthier life.

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Mindsip insights from this episode:

Incorporate colorful foods to prevent long latency deficiency diseases

A long-term lack of phytochemicals, the compounds that give plants their color, can lead to 'long latency deficiency diseases' like cancer and dementia.

#cancer

#nutrition

Utilize Seed DS-01 Daily Synbiotic for clear, hydrated skin

The Seed DS-01 Daily Synbiotic contains specific probiotic strains that are clinically validated to support clear and hydrated skin through the gut-skin axis.

#probiotics

#skin

Practice immuno-rejuvenation for a healthier immune system

Instead of just 'boosting' your immune system, you can practice 'immuno-rejuvenation' because your immune cells completely turn over every 120 days.

#immune-system

#regeneration

Understand three systems connecting body to the world

Your body has only three systems that constantly communicate with the outside world: the nervous system, the mucosal surfaces like the gut, and the immune system.

#immune-system

#nervous-system

Prioritize mitochondrial health to support energy-hungry immune system

When you are ill, your immune system can consume up to 50% of your body's total metabolic energy, highlighting the importance of mitochondrial health.

#immune-system

#mitochondria

Train innate immune system with polyphenols for resilience

The innate immune system, your body's first line of defense, can be trained to be more resilient by consuming polyphenols from plants.

#immune-system

#polyphenols

Utilize Himalayan Tartary Buckwheat to enhance immune regulation

Himalayan Tartary Buckwheat is an ancient, gluten-free plant containing high levels of phytochemicals that can help regulate and train your immune system.

#immune-system

#nutrition

Detect Alzheimer's risk early with P-Tau217 blood test

A biomarker called P-Tau217 can be detected in the blood to identify Alzheimer's risk decades before any symptoms appear, allowing for early intervention.