How Relationships Heal Inflammation, Trauma, and Your Nervous

Mark Hyman

Aug 18, 2025

Episode description

Relationships have the power to change lives in ways both visible and hidden. Deep, supportive bonds can quiet inflammation in the body, protect against disease, and anchor people through decades of triumphs and trials. Communities that come together—whether in small groups at a church or around a shared health goal—often achieve far more than individuals working alone, sometimes transforming their health on a massive scale. Lifelong friends celebrate each other’s victories without jealousy, weather hardship side by side, and dare to speak difficult truths even at the risk of the relationship. Yet, many remain in unfulfilling connections out of fear of loneliness, forgetting that genuine, vulnerable connection is not just emotionally nourishing—it is essential to human health and resilience.

In this episode, I talk with Simon Sinek, Esther Perel, and Angelika Alana about how relationships are vital not just for emotional health, but for physical wellbeing and can be a great source of growth and healing.

Simon is a spark that ignites passion and ideas. He envisions a world where people wake up inspired, feel safe, and end their day fulfilled. As an unshakeable optimist and trained ethnographer, Simon is fascinated by people and organizations that make a lasting impact. He has discovered remarkable patterns in how they think, act, and communicate, revealing how people perform at their best. Simon is widely known for his TED Talk on "WHY" and his viral video on millennials in the workplace. Through bestselling books like Start with WHY and his podcast A Bit of Optimism, he continues to inspire. Founder of The Optimism Company and Optimism Press, Simon shares innovative views on leadership, attracting international attention. He also works with the U.S. government, the RAND Corporation, and in 2021, founded The Curve to reform modern policing, advancing justice with dignity, equity, and fairness.

Psychotherapist and New York Times bestselling author Esther Perel is recognized as one of today’s most insightful and original voices on modern relationships. Fluent in nine languages, she helms a therapy practice in New York City and serves as an organizational consultant for Fortune 500 companies around the world. Her celebrated TED Talks have garnered more than 30 million views and her bestselling books, Mating in Captivity and The State of Affairs, are global phenomena translated into nearly 30 languages. Esther is also an executive producer and host of the popular podcasts Where Should We Begin? and How’s Work? Her latest project is Where Should We Begin - A Game of Stories with Esther Perel.

Angelika Alana is the founder and CEO of the Somatic Healing Institute. She has been featured in Vanity Fair, Well+Good, and Modern Luxury. She certifies coaches and facilitators in her transformational body-based healing method. She has travele

Episode description

Relationships have the power to change lives in ways both visible and hidden. Deep, supportive bonds can quiet inflammation in the body, protect against disease, and anchor people through decades of triumphs and trials. Communities that come together—whether in small groups at a church or around a shared health goal—often achieve far more than individuals working alone, sometimes transforming their health on a massive scale. Lifelong friends celebrate each other’s victories without jealousy, weather hardship side by side, and dare to speak difficult truths even at the risk of the relationship. Yet, many remain in unfulfilling connections out of fear of loneliness, forgetting that genuine, vulnerable connection is not just emotionally nourishing—it is essential to human health and resilience.

In this episode, I talk with Simon Sinek, Esther Perel, and Angelika Alana about how relationships are vital not just for emotional health, but for physical wellbeing and can be a great source of growth and healing.

Simon is a spark that ignites passion and ideas. He envisions a world where people wake up inspired, feel safe, and end their day fulfilled. As an unshakeable optimist and trained ethnographer, Simon is fascinated by people and organizations that make a lasting impact. He has discovered remarkable patterns in how they think, act, and communicate, revealing how people perform at their best. Simon is widely known for his TED Talk on "WHY" and his viral video on millennials in the workplace. Through bestselling books like Start with WHY and his podcast A Bit of Optimism, he continues to inspire. Founder of The Optimism Company and Optimism Press, Simon shares innovative views on leadership, attracting international attention. He also works with the U.S. government, the RAND Corporation, and in 2021, founded The Curve to reform modern policing, advancing justice with dignity, equity, and fairness.

Psychotherapist and New York Times bestselling author Esther Perel is recognized as one of today’s most insightful and original voices on modern relationships. Fluent in nine languages, she helms a therapy practice in New York City and serves as an organizational consultant for Fortune 500 companies around the world. Her celebrated TED Talks have garnered more than 30 million views and her bestselling books, Mating in Captivity and The State of Affairs, are global phenomena translated into nearly 30 languages. Esther is also an executive producer and host of the popular podcasts Where Should We Begin? and How’s Work? Her latest project is Where Should We Begin - A Game of Stories with Esther Perel.

Angelika Alana is the founder and CEO of the Somatic Healing Institute. She has been featured in Vanity Fair, Well+Good, and Modern Luxury. She certifies coaches and facilitators in her transformational body-based healing method. She has travele

Mindsip insights from this episode:

Utilize therapy to resolve friendship struggles

Just as with a struggling marriage, you can take a struggling friendship to therapy to work through issues rather than letting it end or sitting in tension.

Identify true friends who celebrate your successes

A closer level of friendship is not just who you call with bad news, but who you can call with amazing news and they feel unbridled joy for you without jealousy.

Join lifelong support groups for enhanced health and longevity

In the blue zone of Okinawa, people are put into lifelong support groups called "moai" from birth, which is a key factor in their health and longevity.

Eliminate contempt to save relationships

According to research by John Gottman, the single most destructive behavior in a relationship is contempt, as it is a form of dehumanization.

Take responsibility for your own needs in relationships

A primary fallacy in relationships is believing your partner's job is to meet your needs, when it is actually your own responsibility to meet your own needs.

Enjoy dessert without stress to protect your health

The cortisol released from stressing about eating a dessert might be worse for your health than the dessert itself, so if you eat it, you should enjoy it.

Leverage group support for superior health outcomes

In a Cleveland Clinic study, small support groups had three times better health outcomes for the same conditions compared to traditional one-on-one doctor visits.

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© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius