How to Get Microplastics Out of Your Body | Mara Labs

Dave Asprey

Jun 4, 2026

Episode description

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal

Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body..

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.

Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time.

They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time.

You'll Learn:

Why microplastics accumulate inside lysosomes and what sulforaphane does to release them
How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin
What an in-house study revealed about how and where microplastics actually leave the body
How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them
Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch
How sulforaphane boosts BDNF and neuroplasticity at the cellular level
What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily
Why losing weight releases st

Mindsip insights from this episode:

Boost brain health with sulforaphane for vivid dreams

About a quarter of people taking Broccolite report vivid dreams, which is a sign of increased Brain-Derived Neurotrophic Factor (BDNF), a key molecule for brain health and neuroplasticity.

#neuroplasticity

#sulforaphane

Reduce indoor air microplastic exposure from synthetic fibers

Over half of our exposure to microplastics comes from indoor air, released from synthetic fibers in rugs, couches, and the lint from your clothes dryer.

#air-quality

#microplastics

Block toxic estrogen with berberine's unique action on c-MYC gene

Berberine has a unique advantage in blocking toxic estrogen by binding to and blocking the activity of the c-MYC gene, which is considered an 'undruggable' cancer target.

#berberine

#estrogen

Excrete microplastics effectively with Broccolite supplement

An in-house study by the creators of Broccolite confirmed that after taking the supplement, microplastics are primarily excreted from the body through feces.

#microplastics

#supplement

Detox during weight loss to manage released toxins

When you diet and lose fat, toxins stored in that fat are released into your body, making it a good idea to take a supplement like Broccolite to help mitigate them.

#detox

#weight-loss

Stimulate all three detox pathways with Broccolite

The supplement Broccolite is unique because it is the only compound known to stimulate all three of the body's primary detoxification pathways: glutathione, glucuronidation, and sulfation.

#detox

#supplement

Rethink home sprouting for reliable sulforaphane production

Testing of seven different organic broccoli sprout seed brands found that six of them lacked the ability to produce sulforaphane, making home sprouting an unreliable method.

#sprout

#sulforaphane

Choose berberine over Valium for better sleep aid

A scientific paper shows that berberine outperforms Valium as a sleep aid, as it can increase serotonin by 30% and dopamine by 25%.

#berberine

#sleep

Utilize sulforaphane to enhance microplastic excretion

Newly discovered research shows that sulforaphane helps the body excrete microplastics by causing lysosomes, the cell's incinerators, to dump their contents.