A Muscle Supplement no one would Expect

Physionic

Jun 18, 2026

Episode description

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Created with Biorender

0:00 - Introduction
0:45 - Mechanistic Intrigue
2:43 - I want to look like Arnold Schwarzenegger
5:43 - I want the Strength of Atlas
6:55 - 4 Factors to Keep in Mind

References*
*Full Funding/Conflicts are provided in the free article (found in email list and Physionic Community Article Library)
[Study 810] Santo André HC, et al. Adv Nutr. 2023;14(1):115-127. doi:10.1016/j.advnut.2022.11.005

[Study 811] Huang YH, et al. Nutrients. 2020;12(12):3739. doi:10.3390/nu12123739

[Study 812] Noreen EE, et al. J Int Soc Sports Nutr. 2010;7:31. doi:10.1186/1550-2783-7-31

[Study 813] Gravina L, et al. Int J Sport Nutr Exerc Metab. 2017;27(4):305-313. doi:10.1123/ijsnem.2016-0325

[Study 814] Smith GI, et al. Am J Clin Nutr. 2015;102(1):115-122. doi:10.3945/ajcn.114.105833

[Study 815] Rolland Y, et al. Nutrients. 2019;11(8):1931. doi:10.3390/nu11081931

[Study 816] Hutchins-Wiese HL, et al. J Nutr Health Aging. 2013;17(1):76-80. doi:10.1007/s12603-012-0415-3

[Study 817] Alkhedhairi SA, et al. Clin Nutr. 2022;41(6):1228-1235. doi:10.1016/j.clnu.2022.04.007

[Study 818] Brook MS, et al. Clin Nutr ESPEN. 2021;46:394-404. doi:10.1016/j.clnesp.2021.09.729

[Study 819] Cornish SM, Chilibeck PD. Appl Physiol Nutr Metab. 2009;34(1):49-59. doi:10.1139/H08-136

[Study 820] Cornish SM, et al. Nutr Res. 2018;60:87-95. doi:10.1016/j.nutres.2018.09.005

[Study 821] Crestani DM, et al. Sport Sci Health. 2017;13(2):259-265. doi:10.1007/s11332-016-0322-9

[Study 822] Da Boit M, et al. Am J Clin Nutr. 2017;105(1):151-158. doi:10.3945/ajcn.116.140780

[Study 823] Dalle S, et al. J Gerontol A Biol Sci Med Sci. 2021;76(3):406-414. doi:10.1093/gerona/glaa309

[Study 824] Logan SL, Spriet LL. PLoS One. 2015;10(12):e0144828. doi:10.1371/journal.pone.0144828

[Study 825] Kunz HE, et al. Nutrients. 2022;14(17):3537. doi:10.3390/nu14173537

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Boost strength with omega-3 supplementation

A meta-analysis shows omega-3 fat supplementation increases muscle strength, even in studies that showed no effect on muscle mass.

Acknowledge mild effects of omega-3 fats on muscle strength

Even if effective for muscle strength or function, the effects of omega-3 fats are expected to be mild and not a cure for muscle atrophy.

Consume 1.4 to 1.5 grams of omega-3s for strength benefits

In studies that did show an effect, the baseline amount of omega-3 fat consumption was around 1.4 to 1.5 grams of DHA and EPA combined.

Enhance neuromuscular junction with omega-3s for better muscle activation

A well-accepted theory is that omega-3s improve the neuromuscular junction, which is how neurons activate muscle cells, rather than directly affecting the muscle cell itself.

Preserve muscle strength with omega-3 consumption alone

Many studies showed that omega-3 consumption alone, without exercise, led to a preservation or slight improvement in muscle strength.

Recognize omega-3s do not enhance muscle mass

A meta-analysis of 14 studies concluded that omega-3 fat supplementation does not meaningfully increase muscle mass.

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