Mastering Sleep, Biohacking & Peptides: A Data-Driven Approach to Longevity with Boris Berjan

Ben Greenfield

Mar 6, 2025

Episode description

I was recently at a health conference and ducked into a hotel room to sit down for a fascinating episode with Boris Berjan, for an episode during which you'll get to explore the powerful role of chronotypes and "zeitgebers"—external cues like light, food, and temperature that regulate your biological rhythm—in optimizing sleep patterns, particularly if you're on the move across different time zones. The word zeitgeber, originating from the German zeit (time) and geber (giver), refers to the environmental signals that help synchronize your internal clock with the external world. Boris and I dive into the hierarchy of sleep, exercise, and nutrition, breaking down how these essential pillars shape the foundation of true health and longevity. Beyond the physical, we explore the deeper connections between spirituality, purpose, and the pursuit of an extended, meaningful life.

Whether you're looking to refine your health, expand your knowledge, or explore the intersection of science and spirituality, this episode is packed with insights to help you on your journey.

Full show notes: https://bengreenfieldlife.com/boris

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Mindsip insights from this episode:

Cultivate spirituality to embrace mortality and find fulfillment

A myopic focus on life extension is futile; a more fulfilling approach is to accept mortality and cultivate a spiritual life that addresses the soul's desire for the eternal.

#longevity

#spirituality

Cycle growth hormone peptides for muscle growth and fat loss

For muscle growth and fat loss, you can cycle growth hormone stimulating peptides like Tesamorelin and Ipamorelin, often combined with CJC 1295, for 12 weeks at a time.

#muscle

#peptides

Avoid intermittent fasting to support circadian biology

Intermittent fasting isn't always great for circadian biology, as delaying your first meal can prevent your body from getting the signal that the day has started.

#circadian

#fasting

Utilize timekeepers to adjust your sleep schedule

You can use 'zeitgebers' (timekeepers) like light exposure, meal timing, and temperature changes to more quickly align your body clock to any time zone or desired sleep schedule.

#circadian

#sleep

Recall your previous day to quiet your mind for sleep

If you are lying awake with ruminating thoughts, try recalling your entire previous day in detail to shift your brain away from forward-thinking and into a state more conducive to sleep.

#mindfulness

#sleep

Prioritize sleep to enhance movement and nutrition

For overall health, prioritize your focus on sleep first, then movement, and finally nutrition, as good sleep provides the willpower for the other two.