The Anti-Aging Chamber That Rewinds Your Biological Clock|Dr. Jason Sonners
Dave Asprey
May 15, 2025
Mindsip insights from this episode:
Utilize soft and hard hyperbaric chambers for targeted inflammatory benefits
New research shows that lower pressure (soft) and higher pressure (hard) hyperbaric chambers can have different, non-overlapping benefits, with lower pressure being more effective for certain inflammatory markers like TNF-alpha.
Prioritize hyperbaric therapy to reduce biological age
A Yale meta-analysis of 51 longevity strategies found hyperbaric therapy to be one of the most powerful for reducing biological age, even more so than diet or exercise in healthy people.
Maximize regenerative benefits with multiple short hyperbaric therapy sessions
Many of hyperbaric therapy's regenerative benefits come not from being under pressure, but from the 'off-gassing' period afterward, which is why multiple shorter sessions can be more effective than one long one.
Investigate telomere length increase through stem cell activation
The observed increase in average telomere length from hyperbaric therapy may not be from lengthening existing telomeres, but from the creation of new, younger cells via stem cell activation.
Utilize red light therapy to enhance hyperbaric oxygen flow
Using red light therapy before a hyperbaric session can vasodilate blood vessels, priming the body for better oxygen flow and enhancing mitochondrial energy production.
Expect sleep score drop when starting hyperbaric therapy
When starting hyperbaric therapy, your resting heart rate may temporarily increase, causing sleep tracker scores to drop even as your deep sleep, REM sleep, and HRV improve.
Timing of antioxidants matters for effective hyperbaric therapy
Avoid taking general antioxidants like glutathione right before a hyperbaric session, as you don't want to blunt the beneficial reactive oxygen species created by the therapy; instead, take them hours later.
Utilize air pressure to enhance stem cell mobilization
A study found that using a soft chamber with pressurized air alone (no extra oxygen) can increase stem cell mobilization by nearly three times.
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