The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D.
Peter Attia
Apr 7, 2025
Mindsip insights from this episode:
Address radiophobia rooted in US Cold War fears
The intense fear of radiation is largely a US-based phenomenon, partly fueled by Cold War fears and lobbying from the oil industry against nuclear power.
Utilize adjuvant radiation therapy to prevent keloid scar recurrence
For debilitating keloid scars, adjuvant radiation therapy (e.g., 12 Gray) immediately after surgical resection is highly effective at preventing the fibroblasts from causing a recurrence.
Utilize IMRT to protect brain areas during radiation therapy
Using intensity-modulated radiation therapy (IMRT), it's now possible to treat the whole brain while carving out and protecting critical areas like the hippocampi to prevent cognitive decline.
Survive bone-only cancer with modern treatments
Patients with cancer that has metastasized only to the bones, even with widespread disease and extremely high tumor markers, can sometimes live for a very long time with modern treatments.
Reevaluate flawed linear no-threshold model for radiation risk
The widely accepted 'linear no-threshold' model for radiation risk, which assumes any dose is harmful, is likely erroneous and based on disproven fruit fly studies from the 1940s.
Utilize AI tests to reduce unnecessary prostate therapy
New AI-based tests like Artera can analyze pathology slides to better stratify risk, potentially allowing a quarter of intermediate-risk prostate cancer patients to avoid androgen deprivation therapy.
Utilize low-dose radiation to heal injuries and reduce inflammation
Routinely used in Germany, a low dose of radiation—typically 3 Gray total over six sessions—has a powerful anti-inflammatory effect for treating tendinitis, arthritis, and plantar fasciitis.
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