The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon

Dave Asprey

May 13, 2025

Episode description

Your brain has a gear you’ve never touched. Psychedelics can shift you into it.

In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science.

You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools.

What You Will Learn in This Episode:

• How psychedelic shrooms unlock flow, focus, and creative power

• Why psilocybin boosts neuroplasticity, mood, and emotional healing

• Microdosing vs. full-dose: what works, when, and how

• How to stack psychedelics with nootropics and other biohacks

• The newest research on brain optimization and long-term benefits

• How to use psychedelics safely, strategically, and for real results

• Why shrooms may be the strongest mental upgrade in your toolkit

Thank you to our sponsors!

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Matt’s Website – https://mattzemon.com/

• Matt's Instagram - https://www.instagram.com/matt.zemon/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live:

Mindsip insights from this episode:

Neutralize EMFs with Quantum Upgrade for enhanced cell recovery

A service called Quantum Upgrade is claimed to use quantum technology to neutralize harmful EMF exposure, improve cell recovery, and increase ATP production by up to 29%.

#EMF

#quantum

Utilize Fatty 15 supplement to slow biological aging

A supplement called Fatty 15 contains C15, a newly discovered essential fat that is claimed to be more effective than metformin or rapamycin at slowing biological aging.

#aging

#supplement

Reconsider origins: Shift belief from apes to divine descent

For 99.99% of human history, we believed we were descended from gods, and only in a tiny slice of Western culture do we believe we ascended from apes.

#evolution

Facilitate healing by empowering self-discovery

A healer cannot actually heal another person or assign meaning to their experience; they can only facilitate a space where that individual can remember who they are and heal themselves.

#empowerment

#healing

Utilize gratitude journaling post-psychedelics to enhance neuroplasticity

Using a gratitude journal for 30 days after a psychedelic experience is critical for taking advantage of the neuroplasticity window to train your mind on the positive.

#neuroplasticity

#psychedelics

Trust yourself instead of asking others what to do

The phrase 'tell me what to do' is dangerous because it means you don't trust yourself and are giving your agency to someone else who may be lost themselves.

#autonomy

#self-awareness

Recognize psychedelics as catalysts for self-awareness integration

Psychedelics are not cures for anything, but rather catalysts or tools that put you in a state where you can remember who you are and then integrate that awareness into your life.

#psychedelics

#self-awareness

Recognize ketamine's addictive potential despite accessibility

Of all the common psychedelic medicines, ketamine is the one with the most addictive potential, despite being the most legally accessible through clinics.

#addiction

#ketamine

Question your psychedelic facilitator before the session

Before a psychedelic session, you should ask the facilitator about their beliefs, what they will say or sing during the journey, and if they will try to sell you anything afterward.