Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking)

Dave Asprey

Aug 7, 2025

Episode description

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation.

In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health.

You’ll Learn:

• Who should use estradiol—and how it can protect brain performance in men

• The real role of testosterone and estradiol synergy in male health and longevity

• How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health

• Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care

• The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15

• What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks

• Why libido and metabolic health are deeply connected

• The dangers of unvetted peptide sources—and what to look for in quality and bioavailability

This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living.

Mindsip insights from this episode:

Experiment with estrogen microdoses to enhance testosterone therapy outcomes

Some men on long-term testosterone therapy are experimenting with injecting microdoses of estrogen (estradiol cypionate) to improve erections, cognition, and well-being.

#estrogen

#testosterone

Utilize J147 to enhance brain mitochondrial activity

The compound J147, a curcumin derivative found in the product Bio Mind, is claimed to be even more potent than creatine for driving mitochondrial activity in the brain.

#cognition

#mitochondria

Prioritize major health issues before biohacking

When starting with peptides or biohacking, prioritize your most significant health issue first instead of trying to fix everything at once.

#biohacking

Microdose Melanotan-1 for deeper meditation focus

Microdosing the peptide Melanotan-1 can help you achieve a state of 'clinical stillness' for deeper and more focused meditation.

#meditation

#peptides

Utilize short-chain peptides for effective oral bio-regulation

Russian bio-regulators work when taken orally because they are very short-chain peptides (2-4 amino acids) that are stable enough to survive the digestive system.

#digestion

#peptides

Utilize Metared for effective fat loss and oxidative waste reduction

The product Metared combines the mitochondrial driver SLU-PP-332 with the uncoupler BAM15, which helps burn fat while also 'scrubbing' the oxidative waste produced.

#mitochondria

#weight-loss

Exercise caution with Adipotide to protect healthy cells

The peptide Adipotide, which is supposed to kill fat cells, should be used with caution as it may also cause apoptosis in healthy cells.

#peptides

#safety

Recognize estrogen's role in male sex drive and cognition

Contrary to popular belief, estrogen is crucial for a man's sex drive and cognition, and being too lean can dangerously lower it.

#cognition

#estrogen

Utilize Testalutin to enhance testosterone production on TRT

The Russian bio-regulator Testalutin can be used to support the body's natural testosterone production, acting as a potentially superior alternative to HCG for men on TRT.

#testosterone

#TRT

Maintain optimal body fat to support hormone balance

For men, maintaining a body fat percentage between 8-12% is optimal, as dropping too low can crash estrogen levels, leading to low libido and brain fog.