Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking)
Dave Asprey
Aug 7, 2025
Mindsip insights from this episode:
Experiment with estrogen microdoses to enhance testosterone therapy outcomes
Some men on long-term testosterone therapy are experimenting with injecting microdoses of estrogen (estradiol cypionate) to improve erections, cognition, and well-being.
Utilize J147 to enhance brain mitochondrial activity
The compound J147, a curcumin derivative found in the product Bio Mind, is claimed to be even more potent than creatine for driving mitochondrial activity in the brain.
Prioritize major health issues before biohacking
When starting with peptides or biohacking, prioritize your most significant health issue first instead of trying to fix everything at once.
Microdose Melanotan-1 for deeper meditation focus
Microdosing the peptide Melanotan-1 can help you achieve a state of 'clinical stillness' for deeper and more focused meditation.
Utilize short-chain peptides for effective oral bio-regulation
Russian bio-regulators work when taken orally because they are very short-chain peptides (2-4 amino acids) that are stable enough to survive the digestive system.
Utilize Metared for effective fat loss and oxidative waste reduction
The product Metared combines the mitochondrial driver SLU-PP-332 with the uncoupler BAM15, which helps burn fat while also 'scrubbing' the oxidative waste produced.
Exercise caution with Adipotide to protect healthy cells
The peptide Adipotide, which is supposed to kill fat cells, should be used with caution as it may also cause apoptosis in healthy cells.
Recognize estrogen's role in male sex drive and cognition
Contrary to popular belief, estrogen is crucial for a man's sex drive and cognition, and being too lean can dangerously lower it.
Utilize Testalutin to enhance testosterone production on TRT
The Russian bio-regulator Testalutin can be used to support the body's natural testosterone production, acting as a potentially superior alternative to HCG for men on TRT.
Maintain optimal body fat to support hormone balance
For men, maintaining a body fat percentage between 8-12% is optimal, as dropping too low can crash estrogen levels, leading to low libido and brain fog.
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