#093 Dr. Luc van Loon: Optimizing Protein Intake & Distribution for Muscle Growth

Rhonda Patrick

30 jul 2024

Episode description

My free omega-3 guide (the ultimate blueprint for choosing a fish oil supplement)

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Dr. Luc van Loon is a renowned figure in the realm of exercise science, particularly celebrated for his deep understanding of protein metabolism, resistance training, and the nuanced role of collagen supplements in sports nutrition. Our conversation is an in-depth discussion on optimal protein intake & distribution strategies for stimulating muscle protein synthesis with delightful detours into insightful discussion of un ique topics like the timing of cold-water immersion.

Timestamps:

(00:00) Introduction
(06:00) Why do we need protein?
(07:04) How the protein RDA (0.8 g/kg) was established
(11:34) Protein turnover in organs (brain, liver, etc.)
(14:54) How much protein do you really need?
(19:42) Recommended protein intake when dieting for weight loss
(20:59) How the body adapts to higher protein
(24:30) Anabolic resistance
(27:29) Protein requirements for overweight & obese individuals
(29:42) Gaining strength vs. muscle mass
(34:04) Optimal protein distribution
(37:49) 20g vs. 100g protein post-workout (Luc van Loon study)
(40:45) Can evening protein consumption stimulate muscle protein synthesis overnight?
(45:29) How does time-restricted feeding affect muscle protein synthesis?
(51:51) Protein before vs. after exercising
(53:41) How does spreading out protein intake affect hypertrophy?
(56:39) Protein shakes vs. animal protein
(59:42) Protein supplementation for weight loss & recomposition
(1:00:58) Casein vs. whey protein for stimulating muscle protein synthesis
(1:03:53) Factors that influence protein's anabolic potential
(1:04:58) Raw eggs vs. cooked — what's better for hypertrophy?
(1:08:51) Plant vs. animal protein
(1:11:52) Plant-based protein powder
(1:16:31) Whey protein isolate vs. concentrate
(1:17:20) How resistance training changes the leucine threshold
(1:20:31) Do high-protein diets cause atherosclerosis?
(1:28:29) How muscle adapts

Episode description

My free omega-3 guide (the ultimate blueprint for choosing a fish oil supplement)

Discover my premium podcast, The Aliquot

Timestamps:

(00:00) Introduction
(06:00) Why do we need protein?
(07:04) How the protein RDA (0.8 g/kg) was established
(11:34) Protein turnover in organs (brain, liver, etc.)
(14:54) How much protein do you really need?
(19:42) Recommended protein intake when dieting for weight loss
(20:59) How the body adapts to higher protein
(24:30) Anabolic resistance
(27:29) Protein requirements for overweight & obese individuals
(29:42) Gaining strength vs. muscle mass
(34:04) Optimal protein distribution
(37:49) 20g vs. 100g protein post-workout (Luc van Loon study)
(40:45) Can evening protein consumption stimulate muscle protein synthesis overnight?
(45:29) How does time-restricted feeding affect muscle protein synthesis?
(51:51) Protein before vs. after exercising
(53:41) How does spreading out protein intake affect hypertrophy?
(56:39) Protein shakes vs. animal protein
(59:42) Protein supplementation for weight loss & recomposition
(1:00:58) Casein vs. whey protein for stimulating muscle protein synthesis
(1:03:53) Factors that influence protein's anabolic potential
(1:04:58) Raw eggs vs. cooked — what's better for hypertrophy?
(1:08:51) Plant vs. animal protein
(1:11:52) Plant-based protein powder
(1:16:31) Whey protein isolate vs. concentrate
(1:17:20) How resistance training changes the leucine threshold
(1:20:31) Do high-protein diets cause atherosclerosis?
(1:28:29) How muscle adapts

Mindsip insights from this episode:

Avoid cold plunges post-resistance training to maximize muscle gains

Using cold water immersion immediately after resistance training can blunt muscle protein synthesis and negatively impact long-term muscle gains.

#cold-therapy

#muscle

Prioritize training consistency over precise protein timing

Exercise sensitizes muscle to protein for up to 24-48 hours, making the consistency of training and meals more important than precise pre- or post-workout timing.

#exercise

#protein

Consume one large protein meal to sustain muscle synthesis for 12 hours

A single large dose of 100 grams of protein can sustain an elevated muscle protein synthesis response for over 12 hours, much longer than the typical 4-6 hours.

#muscle

#protein

Base protein needs on fat-free mass for effective weight management

If you are overweight, you should base your protein requirements on your fat-free mass rather than your total body weight.

#protein

#weight-loss

Leverage exercise to counteract hormonal changes on muscle strength

Exercise is so powerful it can fully overcome the negative effects of hormonal changes, such as low testosterone from androgen deprivation therapy, on muscle mass and strength.

#exercise

#muscle

Cook eggs to enhance protein absorption

Cooking eggs denatures the protein, making the amino acids much more rapidly available for your body compared to consuming them raw.

#nutrition

#protein

Combat anabolic resistance through physical activity

Much of the age-related anabolic resistance can be overcome by physical activity, suggesting it's largely secondary to a sedentary lifestyle rather than aging itself.