
A Tiny Dose — A Massive Alzheimer’s Protection
Physionic
18 oct 2025
Mindsip insights from this episode:
Break negative feedback loop of amyloid plaques in Alzheimer's
The amyloid plaques produced in Alzheimer's can themselves further stimulate the problematic GSK3 enzyme, creating a negative feedback loop.
Utilize lithium to inhibit Alzheimer's disease mechanism
Elemental lithium can directly bind to and inhibit the GSK3 enzyme, counteracting a primary mechanism that promotes Alzheimer's disease.
Understand GSK3's role in tau protein tangles and neuron stability
When GSK3 hyper-tags tau proteins, they stop stabilizing the neuron's transport highways (microtubules) and instead scrunch up to form tangles.
Target GSK3 to inhibit amyloid plaque formation
GSK3 promotes amyloid plaque formation not by acting on the cutting enzymes directly, but by tagging precursor proteins, making them more attractive to be cut.
Investigate lithium and magnesium interaction for brain health
There is an interesting interaction between lithium and magnesium that may influence its effects on the GSK3 enzyme and overall brain health.
Target GSK3 enzyme to combat Alzheimer's pathology
An enzyme called GSK3 is a key driver of Alzheimer's pathology by destabilizing brain cells and encouraging the buildup of protein tangles.
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