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In this “Ask Me Anything” (AMA) episode, Peter dives back into the increasingly popular topic of GLP-1 agonists, such as Ozempic and Mounjaro, which have garnered widespread attention for their ability to promote weight loss. Peter covers the latest findings in this rapidly evolving landscape, including new insights into their long-term efficacy, side effects, and what happens when the drug is discontinued. Peter also explores their impact on body composition and how resistance training interacts with these treatments. Additionally, he compares different GLP-1 receptor agonists and discusses promising new drugs in the pipeline. Finally, Peter addresses questions about the role of compounding pharmacies in the GLP-1 agonist market, compares oral vs. injectable options, and provides key considerations for anyone deciding whether to use a GLP-1 agonist for weight loss.

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We discuss:

• The rapidly evolving landscape of GLP-1 agonists [2:15];

• The mechanism of GLP-1 agonists, their origin as diabetes treatments, and how they evolved into weight-loss drugs [6:45];

• Overview of new data and open questions related to the benefits and risks of GLP-1 agonists [10:30];

• New insights into the long-term safety of GLP-1 agonists, side effects, and more [16:45];

• The long-term efficacy of GLP-1 agonists, financial barriers, and more [19:45];

• The mechanisms behind GLP-1 agonists' ability to promote weight loss [22:00];

• New data o