The Most Potent Longevity Hormone you’ve Never Heard - and How to Activate it, Naturally - Mindsip

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
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*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

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0:00 - Introduction
0:50 - The Hormone and Longevity
4:10 - More Exciting Data
8:35 - Ceramides
9:50 - Bringing this back to Humans... and Increasing FGF21
12:59 - A few cautions...
14:17 - Main Points

References
[Study 496] Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5(6):415‑425. doi:10.1016/j.cmet.2007.05.003

Funding/Conflicts: Miced Funding [Public funding included grants from the National Institutes of Health (NIH), specifically R01AG057914 and U01AG077925, as well as additional support from the National Institute of General Medical Sciences (R35GM142514) and the National Institute of Diabetes and Digestive and Kidney Diseases (F32DK136283). Non-profit funding came from the Chan Zuckerberg Biohub, the American Federation for Aging Research, the Simons Foundation, the Glenn Foundation for Medical Research, and the Buck Institute Impact Circle.] // Potential direct Conflicts of Interest [J.S.B. is a founder of several biotechnology companies, including Altos Labs, Unity Biotechnology, Napa Therapeutics, Meira GTX, Centaura, and Eigen Therapeutics. Additionally, D.J.G. is a co-founder of Fauna Bio. All other authors declared no competing interests.]

[Study 488] Nicolaisen TS, Lyster AE, Sjøberg KA, et al. Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. Nat Metab. Published online March 6, 2025. doi:10.1038/s42255-025-01236-7

Funding/Conflicts of Interest: Mixed Funding [Public: Independent Research Fund Denmark/Medicine to B.K.; European Foundation for the Study of Diabetes (Future Leader Award NNF20SA0066171 to N.K., Lilly award to A.J.R.; Industry: Novo Nordisk Foundation (NNF17OC0029054, NNF20SA0066171, NNF22OC0074110, NNF18CC0034900, NNF23SA0084103); DFG Emmy Noether (KR5166/2 to N.K. ), DFG BATenergy (TRR 333/1–450149205 to N.K. ); The Novo Nordisk Foundation Center for Basic Metabolic Research, partially funded by an unconditional donation from the Novo Nordisk Foundation) // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#antiaging #longevity

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:50 - The Hormone and Longevity
4:10 - More Exciting Data
8:35 - Ceramides
9:50 - Bringing this back to Humans... and Increasing FGF21
12:59 - A few cautions...
14:17 - Main Points

References
[Study 496] Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5(6):415‑425. doi:10.1016/j.cmet.2007.05.003

Funding/Conflicts: Miced Funding [Public funding included grants from the National Institutes of Health (NIH), specifically R01AG057914 and U01AG077925, as well as additional support from the National Institute of General Medical Sciences (R35GM142514) and the National Institute of Diabetes and Digestive and Kidney Diseases (F32DK136283). Non-profit funding came from the Chan Zuckerberg Biohub, the American Federation for Aging Research, the Simons Foundation, the Glenn Foundation for Medical Research, and the Buck Institute Impact Circle.] // Potential direct Conflicts of Interest [J.S.B. is a founder of several biotechnology companies, including Altos Labs, Unity Biotechnology, Napa Therapeutics, Meira GTX, Centaura, and Eigen Therapeutics. Additionally, D.J.G. is a co-founder of Fauna Bio. All other authors declared no competing interests.]

[Study 488] Nicolaisen TS, Lyster AE, Sjøberg KA, et al. Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men. Nat Metab. Published online March 6, 2025. doi:10.1038/s42255-025-01236-7

Funding/Conflicts of Interest: Mixed Funding [Public: Independent Research Fund Denmark/Medicine to B.K.; European Foundation for the Study of Diabetes (Future Leader Award NNF20SA0066171 to N.K., Lilly award to A.J.R.; Industry: Novo Nordisk Foundation (NNF17OC0029054, NNF20SA0066171, NNF22OC0074110, NNF18CC0034900, NNF23SA0084103); DFG Emmy Noether (KR5166/2 to N.K. ), DFG BATenergy (TRR 333/1–450149205 to N.K. ); The Novo Nordisk Foundation Center for Basic Metabolic Research, partially funded by an unconditional donation from the Novo Nordisk Foundation) // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#antiaging #longevity