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0:00 - Introduction
0:53 - MOTS-c on Fat Metabolism inside the Cells
2:53 - Blocking Fat Gain
4:49 - How does MOTS-c work?
5:58 - Some Cautions..
7:00 - Whole Body Fat Metabolism and Age Effect
8:12 - Human Data
10:07 - Main Points

Reference
[Study 439] Reynolds, J.C., Lai, R.W., Woodhead, J.S.T., Joly, J.H., Mitchell, C.J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N.A., Benayoun, B.A., Merry, T.L., & Lee, C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. ​ Nat Commun. ​ 2021;12(1):470. doi:10.1038/s41467-020-20790-0. ​

Funding/Conflicts: Mixed Funding [American Federation for Aging Research (AFAR), National Institute on Aging (T32 AG052374, P01AG034906, R00AG049934, R01AG052258), USC Manning Endowed Fellowship (to J.C.R.), Mork Graduate Fellowship, USC Viterbi School of Engineering (to J.H.J.), USC Viterbi School of Engineering (to N.A.G.), Rose Hills Foundation (innovator grant), NAVIGAGE Foundation (seed grant), Hanson-Thorell Family, Rutherford Discovery Fellowship and Marsden Fund Fast Start Grant (to T.L.M.), Ellison Medical Foundation (EMF)] // Potential direct Conflicts of Interest [Two authors, P.C. and C.L., are listed as consultants and shareholders of CohBar, Inc., a biotechnology company focused on mitochondrial-derived peptides, including MOTS-c; All other authors declared no competing interests​]

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