Anti-Aging Molecule Rapamycin’s Anti-Alzheimer’s Promise: A Mitochondria Story

Physionic

Nov 20, 2024

Episode description

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0:00 - Introduction
0:42 - Rapamycin's relationship to Alzheimer's Disease
1:36 - Rapamycin's Mitochondria Connection
6:01 - What triggers mitochondrial elimination?
9:20 - How would clearing out mitochondria help?

References
[Study 357] Wang H, Fu J, Xu X, Yang Z, Zhang T. Rapamycin Activates Mitophagy and Alleviates Cognitive and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2021;76(10):1707-1713. doi:10.1093/gerona/glab142

Funding/Conflicts: Public Funding [National Natural Science Foundation of China] // No Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

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If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#alzheimerscare #alzheimersprevention #alzheimerawareness

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:42 - Rapamycin's relationship to Alzheimer's Disease
1:36 - Rapamycin's Mitochondria Connection
6:01 - What triggers mitochondrial elimination?
9:20 - How would clearing out mitochondria help?

References
[Study 357] Wang H, Fu J, Xu X, Yang Z, Zhang T. Rapamycin Activates Mitophagy and Alleviates Cognitive and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2021;76(10):1707-1713. doi:10.1093/gerona/glab142

Funding/Conflicts: Public Funding [National Natural Science Foundation of China] // No Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#alzheimerscare #alzheimersprevention #alzheimerawareness

Mindsip insights from this episode:

Restore mitochondrial health with rapamycin in Alzheimer's models

The addition of rapamycin was shown to recover a large amount of the mitochondrial membrane potential lost in Alzheimer's disease models.

Utilize rapamycin to prevent neuron death by reducing pro-apoptotic proteins

Rapamycin was shown to eliminate the increase of pro-apoptotic proteins like BAX, which would otherwise lead to the death of neurons.

Target damaged mitochondria for elimination through Parkin activation

A compromised membrane potential in a mitochondrion is a key trigger that attracts destruction enzymes like Parkin to eliminate it.

Isolate mitochondria to uncover autophagy protein concentration

By isolating mitochondria from the rest of the cell, researchers discovered that key autophagy proteins were concentrated there, a detail missed when analyzing the whole cell.

Activate mitophagy with rapamycin to enhance brain health

Rapamycin appears to activate a process called mitophagy, which specifically targets and destroys damaged mitochondria within brain cells.

Tag damaged mitochondria for autophagy with Parkin enzyme

The enzyme Parkin tags damaged mitochondria, which then recruits the protein P62 to signal the autophagy machinery for destruction.

Protect mitochondrial health to combat Alzheimer's impact

In Alzheimer's disease models, the mitochondrial membrane potential, a key indicator of health, is severely compromised or 'crushed'.

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