
Anti-Aging Molecule Rapamycin’s Anti-Alzheimer’s Promise: A Mitochondria Story
Physionic
Nov 20, 2024
Mindsip insights from this episode:
Restore mitochondrial health with rapamycin in Alzheimer's models
The addition of rapamycin was shown to recover a large amount of the mitochondrial membrane potential lost in Alzheimer's disease models.
Utilize rapamycin to prevent neuron death by reducing pro-apoptotic proteins
Rapamycin was shown to eliminate the increase of pro-apoptotic proteins like BAX, which would otherwise lead to the death of neurons.
Target damaged mitochondria for elimination through Parkin activation
A compromised membrane potential in a mitochondrion is a key trigger that attracts destruction enzymes like Parkin to eliminate it.
Isolate mitochondria to uncover autophagy protein concentration
By isolating mitochondria from the rest of the cell, researchers discovered that key autophagy proteins were concentrated there, a detail missed when analyzing the whole cell.
Activate mitophagy with rapamycin to enhance brain health
Rapamycin appears to activate a process called mitophagy, which specifically targets and destroys damaged mitochondria within brain cells.
Tag damaged mitochondria for autophagy with Parkin enzyme
The enzyme Parkin tags damaged mitochondria, which then recruits the protein P62 to signal the autophagy machinery for destruction.
Protect mitochondrial health to combat Alzheimer's impact
In Alzheimer's disease models, the mitochondrial membrane potential, a key indicator of health, is severely compromised or 'crushed'.
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