It’s Not a Stroke — It’s Your Arteries Slowly Attacking your Brain

Physionic

Nov 24, 2025

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomyJOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6HIRE ME FOR CONSULTING: Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:34 - Arterial Plaque and Brain Damage6:49 - Main PointsReducing Plaque in your Arteries: https://www.youtube.com/watch?v=XDPgJcVXeNcReferences[Study 545] Zhang H, Zhou LQ, Yang S, Dong MH, Chen L, Lu YL, et al. The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia. Cell Metab. 2025;37(8):1636-1654. doi:10.1016/j.cmet.2025.04.009Public Funding: STI2030-Major Projects (2022ZD0204700); National Natural Science Foundation of China (82471353, 82271341, 82371404, 81873743, 82301510, 92248304); Hubei Province Key Research and Development Program Project (2023BCB148); Natural Science Foundation for Distinguished Young Scholars of Hubei (2024AFA050); Basic Research Support Program of Huazhong University of Science and Technology; Knowledge Innovation Program of Wuhan Shuguang Project (2022020801020454) // No direct Conflicts of InterestCRITIQUES, RULES, AND NOTESBe aware of the following rules before posting comments:- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES:If your comment is rude, you will be banned.If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomyJOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6HIRE ME FOR CONSULTING: Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:34 - Arterial Plaque and Brain Damage6:49 - Main PointsReducing Plaque in your Arteries: https://www.youtube.com/watch?v=XDPgJcVXeNcReferences[Study 545] Zhang H, Zhou LQ, Yang S, Dong MH, Chen L, Lu YL, et al. The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia. Cell Metab. 2025;37(8):1636-1654. doi:10.1016/j.cmet.2025.04.009Public Funding: STI2030-Major Projects (2022ZD0204700); National Natural Science Foundation of China (82471353, 82271341, 82371404, 81873743, 82301510, 92248304); Hubei Province Key Research and Development Program Project (2023BCB148); Natural Science Foundation for Distinguished Young Scholars of Hubei (2024AFA050); Basic Research Support Program of Huazhong University of Science and Technology; Knowledge Innovation Program of Wuhan Shuguang Project (2022020801020454) // No direct Conflicts of InterestCRITIQUES, RULES, AND NOTESBe aware of the following rules before posting comments:- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES:If your comment is rude, you will be banned.If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Protect brain's communication pathways from plaque damage

The attack on the brain results in white matter lesions, which is damage to the protective myelin sheath that insulates your brain's communication pathways.

Address trapped immune cells to combat arterial plaque damage

The damaging messages originate from your own immune cells that become overburdened with cholesterol in arterial plaque, turning into 'foam cells.'.

Recognize plaque's harmful exosomes traveling to the brain

Plaque in your arteries releases tiny packages called exosomes, which travel through the body to the brain to deliver their harmful message.

Protect brain's immune cells from exosome hijacking

Exosomes from arterial plaque don't cause damage directly, but instead hijack the brain's own immune cells, called microglia, causing them to become destructive.

Reduce plaque to prevent brain cell inflammation

Exosomes from plaque cause brain immune cells to increase the production of pro-inflammatory molecules and reduce the activity of their mitochondria.

Protect your brain from arterial plaque damage

Arterial plaque actively harms your brain by sending out damaging messages, even when the plaque is not located in arteries near your brain.

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