Are “Poop Pills” The Ultimate Bowel Biohack Of The Future? The Science of Fecal Microbiota Transplants (FMT) with Jason Klop.
Ben Greenfield
Apr 11, 2026
Episode description
Full Show Notes: bengreenfieldlife.com/fmt
In this episode, you'll get to uncover one of the most intriguing developments in gut health—fecal microbiota transplants (FMTs). Joining me is Jason Klop, CEO of Novel Biome, who brings cutting-edge insight into how FMT is transforming from an obscure, hospital-based procedure into an accessible, precise, and surprisingly simple tool for optimizing your microbiome at home.
We’ll break down how FMT is now being used for everything from irritable bowel issues to food sensitivities, and why the technology has advanced well beyond its origins. You'll also hear about the meticulous screening behind “super donors,” the science of oral FMT capsules, and the real-world results you can expect—including my own personal experience. Whether you’re looking to boost your gut health, support your immune system, or simply curious about the connection between your microbiome and overall vitality, this episode has what you need to stay on the cutting edge of holistic wellness.
Jason Klop brings a clinical background in naturopathic medicine to his role as founder and CEO of Novel Biome, Canada's first licensed manufacturer of Fecal Microbiota Transplant (FMT) products. Having personally treated hundreds of patients with FMT in clinical practice, Jason saw a gap in the availability of safe, standardized microbiome restoration therapies and set out to build the infrastructure himself. Today, Novel Biome supplies FMT products to clinics, hospitals, and clinical trials around the world.
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Mindsip insights from this episode:
Understand strict donor screening to join elite 1%
The donor screening process is so strict—evaluating diet, antibiotic history, and family medical history—that less than 1% of applicants are accepted into the program.
Avoid restrictive diets to preserve gut bacterial diversity
Long-term, highly restrictive diets like the carnivore diet can lead to the permanent loss of gut bacterial species by starving them of diverse fibers.
Avoid hunter-gatherer stool donors for Western gut health
A stool donor from a hunter-gatherer tribe is not ideal for a Westerner because their microbes may not survive in a Western gut and could carry parasites.
Consider FMT for safe health improvement
The safety profile for FMT is so high that almost anyone is a candidate, with the only major pause being for individuals with a literally non-existent immune system.
Prepare for FMT with pre-treatment clean out phase
Most FMT research involves a pre-treatment "clean out" phase to create more space for new microbes to engraft with less competition from existing bugs.
Utilize FMT capsules for effective C. Diff treatment
For treating C. Diff, oral FMT capsules have a 90% cure rate, which is comparable to a colonoscopy and significantly better than the 60% rate for enemas.
Utilize fecal transplants to restore crucial microbes
Fecal transplants are currently the only known way to replace certain crucial microbes, such as oxalate-degrading bacteria, which cannot be restored through probiotics.
Utilize FMT to significantly reduce food sensitivities
An FMT can lead to a dramatic reduction in food sensitivities, in one case an 80% reduction, by healing the gut lining and re-educating the immune system.
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