The Potent Brain & Body Ketone Fuel You’ve Probably Never Heard Of: The Science Of R3HBG With Tecton’s Dr. Mike Chesne
Ben Greenfield
Jul 11, 2026
Episode description
Full show notes: https://bengreenfieldlife.com/tectonpodcast
In this episode with Dr. Mike Chesne, founder of Tecton Ketones™, you'll hear how a traumatic brain injury sustained in combat led him from Army Special Forces medic to ketone biochemist, and why he eventually built what he believes is a meaningfully better exogenous ketone molecule than anything else currently on the market. We get into the real biochemical differences between ketone salts, ketone esters, and bioidentical beta-hydroxybutyrate, why the liver matters so much in how these molecules get metabolized, and a full walkthrough of Tecton's plant-based liposomal delivery system. You'll also hear about all four Tecton product formulations, the dual agonist effect ketones may have on hunger and fullness signaling, and the proposed mechanism behind why ketones may improve exercise recovery.
Dr. Mike Chesne founded Tecton after a 25-year career in United States Army Special Operations. His interest in exogenous ketones began after researching a DARPA-funded project led by Oxford University and the NIH.
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Mindsip insights from this episode:
Avoid 1,3-butanediol ketones to preserve NAD levels
Ketones made from 1,3-butanediol must be processed by the liver, which burns up the body's valuable NAD pool in the process.
Maximize ketone salt bioavailability by choosing L-BHB forms
Most ketone salts are a 'racemic mix,' meaning about 50% is the L-BHB form which the human body does not produce or metabolize, making it non-bioavailable.
Utilize Thymoquin to support healthy cortisol levels and manage stress
A specific black seed oil supplement called Thymoquin has been clinically studied for its ability to support healthy cortisol levels and help the body adapt to stress.
Utilize ketones to enhance workout recovery
Ketones may improve recovery by being a cleaner fuel source that doesn't produce as much lactate as glucose, reducing the metabolic stress and buffering required post-exercise.
Implement cyclo ketosis diet for enhanced sleep and performance
A 'cyclo ketosis' diet involves using exogenous ketones and restricting carbs during the day, followed by a carbohydrate refeed in the evening to support sleep and athletic performance.
Utilize plant-based nano delivery for enhanced bioavailability
A proprietary 'green nanotechnology' uses plant proteins like pea or soy to encapsulate molecules, increasing their bioavailability without using metals.
Utilize specialized ketone shots for enhanced performance and satiety
Tectone offers four specialized ketone shots: Electrolyte for athletes, Cognition with Lion's Mane, a low-dose Caffeine version, and a GLP-1 version with 5-HTP for satiety.
Utilize R3HBG ketone to bypass liver stress
A new ketone molecule called R3HBG is metabolized by lipase enzymes directly in the digestive system, completely bypassing the liver and avoiding potential hepatic stress.
Utilize Lima Laser to influence longevity and inflammation genes in skin
The Lima Laser is claimed to influence 45 longevity and inflammation-related genes in the skin, compared to a standard LED device which only influenced one in a peer-reviewed study.
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