Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.

Peter Attia

Jan 6, 2025

Episode description

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Trenna Sutcliffe is a developmental behavioral pediatrician and the founder and medical director of the Sutcliffe Clinic in the San Francisco Bay Area, where she partners with families to provide care for children facing behavioral challenges, developmental differences, and school struggles. In this episode, Trenna shares her journey into developmental and behavioral pediatrics, including her pioneering work at Stanford and her expertise in autism, ADHD, and anxiety—the "three As." She explores the diagnostic processes, the overlap and comorbidities of these conditions, and the importance of personalized treatment plans that address both medical and environmental factors. Trenna offers valuable insights into the changing prevalence of autism, the impact of evolving diagnostic criteria, and the range of therapies and medications available to support children and their families. She also discusses the challenges in accessing care and the critical need for a holistic approach that bridges healthcare and education.

We discuss:

  • Trenna’s passion for developmental-behavioral pediatrics (DBP), and the process of diagnosing anxiety, ADHD, and autism [3:15];

  • Understanding anxiety and ADHD: assessing impairment and self-esteem and identifying anxiety and emotional well-being in young patients [9:45];

  • The evolving diagnosis of autism: understanding the spectrum and individual needs [16:30];

  • The dramatic rise in autism spectrum disorder (ASD): genetics, environment, expanded diagnostic criteria, and more [25:45];

  • Exploring epigenetics and the potential multigenerational impact of environment exposures on susceptibility to certain disorders [37:15];

  • The evolution of autism classifications, and the particular challenges for children with level 1 (mild) autism due to a lack of support [41:15];

  • The broadening of the autism spectrum: benefits and risks of expanded diagnostic criteria and the need for future frameworks to focus on better outcomes [48:00];

  • The overlap between ASD, ADHD, and anxiety [57:15];

  • Understanding oppositional defiant disorder, and the importance of understanding the “why” behind a behavior when creating treatment plans [1:00:45];

  • De

Episode description

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

Trenna Sutcliffe is a developmental behavioral pediatrician and the founder and medical director of the Sutcliffe Clinic in the San Francisco Bay Area, where she partners with families to provide care for children facing behavioral challenges, developmental differences, and school struggles. In this episode, Trenna shares her journey into developmental and behavioral pediatrics, including her pioneering work at Stanford and her expertise in autism, ADHD, and anxiety—the "three As." She explores the diagnostic processes, the overlap and comorbidities of these conditions, and the importance of personalized treatment plans that address both medical and environmental factors. Trenna offers valuable insights into the changing prevalence of autism, the impact of evolving diagnostic criteria, and the range of therapies and medications available to support children and their families. She also discusses the challenges in accessing care and the critical need for a holistic approach that bridges healthcare and education.

We discuss:

  • Trenna’s passion for developmental-behavioral pediatrics (DBP), and the process of diagnosing anxiety, ADHD, and autism [3:15];

  • Understanding anxiety and ADHD: assessing impairment and self-esteem and identifying anxiety and emotional well-being in young patients [9:45];

  • The evolving diagnosis of autism: understanding the spectrum and individual needs [16:30];

  • The dramatic rise in autism spectrum disorder (ASD): genetics, environment, expanded diagnostic criteria, and more [25:45];

  • Exploring epigenetics and the potential multigenerational impact of environment exposures on susceptibility to certain disorders [37:15];

  • The evolution of autism classifications, and the particular challenges for children with level 1 (mild) autism due to a lack of support [41:15];

  • The broadening of the autism spectrum: benefits and risks of expanded diagnostic criteria and the need for future frameworks to focus on better outcomes [48:00];

  • The overlap between ASD, ADHD, and anxiety [57:15];

  • Understanding oppositional defiant disorder, and the importance of understanding the “why” behind a behavior when creating treatment plans [1:00:45];

  • De

Mindsip insights from this episode:

Investigate grandparent's environmental impact on grandchildren's health

A controversial theory suggests that a grandparent's environmental exposures could cause heritable epigenetic changes that are passed down to their grandchild.

Address underlying causes of oppositional behavior in children

Oppositional behavior in a child is often a symptom driven by an underlying cause like anxiety, impulsivity from ADHD, or sensory overload, not just a standalone disorder.

Choose ADHD medication brands wisely for effective treatment

Even when ADHD medications like Ritalin and Focalin share the same active ingredient, a child can respond very differently due to variations in the drug's release mechanism.

Question the validity of man-made diagnoses for mental health conditions

Diagnoses for conditions like anxiety, ADHD, and autism are based on man-made clinical checklists, not biological markers like blood tests or brain scans.

Recognize impairment to understand anxiety and ADHD traits

Having traits of anxiety or ADHD is normal, and a diagnosis is only warranted when those traits create significant impairment in a person's ability to function.

Assess self-esteem in children through hypothetical scenarios

To assess a young child's self-esteem, clinicians may ask them about a hypothetical third person, as it is often easier for the child to project their own feelings and experiences.

Understand autism through the 'ten-hit' model

The cause of autism is not a single factor but is thought to be a 'ten-hit' model, where multiple genetic, environmental, and epigenetic hits combine to cause the condition.

Recognize high heritability of autism for better understanding

The genetic heritability of autism is over 90%, which is believed to be higher than any other condition in the DSM, including schizophrenia and bipolar disorder.

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