Restricting 2 Amino Acids eliminated Cancer in Clinical Trial!

Physionic

Dec 22, 2025

Episode description

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Created with Biorender

Vitamin C on Cancer - an Untold Story: https://youtu.be/e6jjRy7fj5E?si=PO8sHlRENl6wjEAl

0:00 - Remarkable Images of Tumor Disappearance
0:25 - The Amino Acids
0:55 - Different Cancers - Not just Colorectal
1:07 - The Protocol Effectiveness
2:10 - Cancer Evasion - A Double Dose Needed
2:45 - The Protocol
3:30 - Not 100% Effective - Why Not?
6:21 - Keep in Mind...
7:39 - Should Glycine Supplementation be Stopped?
8:43 - Main Points

Reference
[Study 561] Tong H, Jiang Z, Song L, et al. Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36(12):2493-2510. doi:10.1016/j.cmet.2024.10.019

Funding / Conflicts: Public: This study was supported by the Science and Technology Program of Sichuan Province (2022NSFSC0774); this study was supported by the National Natural Science Foundation of China (82273030 and 82472869); no public-sector conflicts of interest were declared; Non-Profit: This study was supported by the 2021 Xinrui Tumor Supportive Treatment Research Public Welfare Project (311221042); no non-profit conflicts of interest were declared; Industry: Junshi Biosciences provided PD-1 inhibitors; Shanghai Sinotech Genomics Co., Ltd. provided single-cell sequencing services and Shanghai Personal Biotechnology Co., Ltd. provided PD-L1 lactylation-related and metabolomics/TCR sequencing services; Recovery Plus Clinic Co. funded targeted amino acid metabolism testing and some other sequencing services for the project; conflicts of interest: C.H. and Z. Lei are shareholders and board members of Recovery Plus Clinic Co., and Z. Long and J.Y. are also members of this company (the authors note potential bias and state independent/unaffiliated researchers were included to mitigate this).

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cancertherapy #cancertreatment #cancerprevention

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

Vitamin C on Cancer - an Untold Story: https://youtu.be/e6jjRy7fj5E?si=PO8sHlRENl6wjEAl

0:00 - Remarkable Images of Tumor Disappearance
0:25 - The Amino Acids
0:55 - Different Cancers - Not just Colorectal
1:07 - The Protocol Effectiveness
2:10 - Cancer Evasion - A Double Dose Needed
2:45 - The Protocol
3:30 - Not 100% Effective - Why Not?
6:21 - Keep in Mind...
7:39 - Should Glycine Supplementation be Stopped?
8:43 - Main Points

Reference
[Study 561] Tong H, Jiang Z, Song L, et al. Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36(12):2493-2510. doi:10.1016/j.cmet.2024.10.019

Funding / Conflicts: Public: This study was supported by the Science and Technology Program of Sichuan Province (2022NSFSC0774); this study was supported by the National Natural Science Foundation of China (82273030 and 82472869); no public-sector conflicts of interest were declared; Non-Profit: This study was supported by the 2021 Xinrui Tumor Supportive Treatment Research Public Welfare Project (311221042); no non-profit conflicts of interest were declared; Industry: Junshi Biosciences provided PD-1 inhibitors; Shanghai Sinotech Genomics Co., Ltd. provided single-cell sequencing services and Shanghai Personal Biotechnology Co., Ltd. provided PD-L1 lactylation-related and metabolomics/TCR sequencing services; Recovery Plus Clinic Co. funded targeted amino acid metabolism testing and some other sequencing services for the project; conflicts of interest: C.H. and Z. Lei are shareholders and board members of Recovery Plus Clinic Co., and Z. Long and J.Y. are also members of this company (the authors note potential bias and state independent/unaffiliated researchers were included to mitigate this).

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#cancertherapy #cancertreatment #cancerprevention

Mindsip insights from this episode:

Eliminate serine and glycine to shrink tumors

A recent human clinical trial showed that eliminating the amino acids serine and glycine from the diet can cause advanced, solid tumors to shrink significantly in just nine weeks.

Ensure adequate nutrition without calorie restriction in cancer protocols

Patients on this cancer protocol were not calorie-restricted and were given enough nutrition (around 30 kcal/kg and 1.5g protein/kg) to maintain their body weight.

Combine amino acid restriction with targeted immunotherapy to combat cancer

Amino acid restriction is not sufficient on its own; it forces cancer cells into a specific vulnerability, allowing targeted immunotherapy to then destroy them effectively.

Navigate glycine paradox to tailor cancer treatments

While this study shows glycine restriction is beneficial, other evidence suggests glycine can help fight cancer, indicating different cancers respond differently to the same treatment.

Leverage diet to empower immune system against cancer

The tumor-fighting effect of serine and glycine restriction is dependent on the immune system's CD8+ cytotoxic T cells, which are enabled to recognize and attack cancer cells.

Do not restrict glycine or serine intake if healthy

The research does not indicate that a healthy person without a cancer diagnosis should limit their glycine or serine consumption based on these findings.

Follow amino acid-restricted diet longer for better tumor outcomes

In the trial, patients who adhered to the amino acid-restricted diet for the longest duration (up to nine weeks) tended to experience better outcomes like tumor stabilization or shrinkage.

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