Restricting 2 Amino Acids eliminated Cancer in Clinical Trial!
Physionic
Dec 22, 2025
Episode description
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Vitamin C on Cancer - an Untold Story: https://youtu.be/e6jjRy7fj5E?si=PO8sHlRENl6wjEAl
0:00 - Remarkable Images of Tumor Disappearance
0:25 - The Amino Acids
0:55 - Different Cancers - Not just Colorectal
1:07 - The Protocol Effectiveness
2:10 - Cancer Evasion - A Double Dose Needed
2:45 - The Protocol
3:30 - Not 100% Effective - Why Not?
6:21 - Keep in Mind...
7:39 - Should Glycine Supplementation be Stopped?
8:43 - Main Points
Reference
[Study 561] Tong H, Jiang Z, Song L, et al. Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36(12):2493-2510. doi:10.1016/j.cmet.2024.10.019
Funding / Conflicts: Public: This study was supported by the Science and Technology Program of Sichuan Province (2022NSFSC0774); this study was supported by the National Natural Science Foundation of China (82273030 and 82472869); no public-sector conflicts of interest were declared; Non-Profit: This study was supported by the 2021 Xinrui Tumor Supportive Treatment Research Public Welfare Project (311221042); no non-profit conflicts of interest were declared; Industry: Junshi Biosciences provided PD-1 inhibitors; Shanghai Sinotech Genomics Co., Ltd. provided single-cell sequencing services and Shanghai Personal Biotechnology Co., Ltd. provided PD-L1 lactylation-related and metabolomics/TCR sequencing services; Recovery Plus Clinic Co. funded targeted amino acid metabolism testing and some other sequencing services for the project; conflicts of interest: C.H. and Z. Lei are shareholders and board members of Recovery Plus Clinic Co., and Z. Long and J.Y. are also members of this company (the authors note potential bias and state independent/unaffiliated researchers were included to mitigate this).
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#cancertherapy #cancertreatment #cancerprevention
Mindsip insights from this episode:
Eliminate serine and glycine to shrink tumors
A recent human clinical trial showed that eliminating the amino acids serine and glycine from the diet can cause advanced, solid tumors to shrink significantly in just nine weeks.
Ensure adequate nutrition without calorie restriction in cancer protocols
Patients on this cancer protocol were not calorie-restricted and were given enough nutrition (around 30 kcal/kg and 1.5g protein/kg) to maintain their body weight.
Combine amino acid restriction with targeted immunotherapy to combat cancer
Amino acid restriction is not sufficient on its own; it forces cancer cells into a specific vulnerability, allowing targeted immunotherapy to then destroy them effectively.
Navigate glycine paradox to tailor cancer treatments
While this study shows glycine restriction is beneficial, other evidence suggests glycine can help fight cancer, indicating different cancers respond differently to the same treatment.
Leverage diet to empower immune system against cancer
The tumor-fighting effect of serine and glycine restriction is dependent on the immune system's CD8+ cytotoxic T cells, which are enabled to recognize and attack cancer cells.
Do not restrict glycine or serine intake if healthy
The research does not indicate that a healthy person without a cancer diagnosis should limit their glycine or serine consumption based on these findings.
Follow amino acid-restricted diet longer for better tumor outcomes
In the trial, patients who adhered to the amino acid-restricted diet for the longest duration (up to nine weeks) tended to experience better outcomes like tumor stabilization or shrinkage.
